Welzenbach K - Search Results

1

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

Wattanasin S, Albert R, Ehrhardt C, Roche D, Sabio M, Hommel U, Welzenbach K, Weitz-Schmidt G. Wattanasin S, et al. Among authors: welzenbach k. Bioorg Med Chem Lett. 2003 Feb 10;13(3):499-502. doi: 10.1016/s0960-894x(02)00991-5. Bioorg Med Chem Lett. 2003. PMID: 12565959

2

Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.

Welzenbach K, Hommel U, Weitz-Schmidt G. Welzenbach K, et al. J Biol Chem. 2002 Mar 22;277(12):10590-8. doi: 10.1074/jbc.M110521200. Epub 2002 Jan 7. J Biol Chem. 2002. PMID: 11781316 Free article.

3

Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.

Ullrich T, Baumann K, Welzenbach K, Schmutz S, Camenisch G, Meingassner JG, Weitz-Schmidt G. Ullrich T, et al. Among authors: welzenbach k. Bioorg Med Chem Lett. 2004 May 17;14(10):2483-7. doi: 10.1016/j.bmcl.2004.03.006. Bioorg Med Chem Lett. 2004. PMID: 15109637

4

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.

Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G. Wattanasin S, et al. Among authors: welzenbach k. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. doi: 10.1016/j.bmcl.2004.11.072. Bioorg Med Chem Lett. 2005. PMID: 15686945

5

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo.

Weitz-Schmidt G, Welzenbach K, Dawson J, Kallen J. Weitz-Schmidt G, et al. Among authors: welzenbach k. J Biol Chem. 2004 Nov 5;279(45):46764-71. doi: 10.1074/jbc.M407951200. Epub 2004 Aug 10. J Biol Chem. 2004. PMID: 15304496 Free article.

6

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U. Kallen J, et al. Among authors: welzenbach k. J Mol Biol. 1999 Sep 10;292(1):1-9. doi: 10.1006/jmbi.1999.3047. J Mol Biol. 1999. PMID: 10493852

7

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U. Weitz-Schmidt G, et al. Among authors: welzenbach k. Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058. Nat Med. 2001. PMID: 11385505

8

Downstream effect profiles discern different mechanisms of integrin αLβ2 inhibition.

Mancuso RV, Welzenbach K, Steinberger P, Krähenbühl S, Weitz-Schmidt G. Mancuso RV, et al. Among authors: welzenbach k. Biochem Pharmacol. 2016 Nov 1;119:42-55. doi: 10.1016/j.bcp.2016.09.002. Epub 2016 Sep 6. Biochem Pharmacol. 2016. PMID: 27613223

9

Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.

Albert R, Hinterding K, Brinkmann V, Guerini D, Müller-Hartwieg C, Knecht H, Simeon C, Streiff M, Wagner T, Welzenbach K, Zécri F, Zollinger M, Cooke N, Francotte E. Albert R, et al. Among authors: welzenbach k. J Med Chem. 2005 Aug 11;48(16):5373-7. doi: 10.1021/jm050242f. J Med Chem. 2005. PMID: 16078855

10

A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood.

Welzenbach K, Mancuso RV, Krähenbühl S, Weitz-Schmidt G. Welzenbach K, et al. Br J Pharmacol. 2015 Oct;172(20):4875-87. doi: 10.1111/bph.13256. Epub 2015 Oct 19. Br J Pharmacol. 2015. PMID: 26224111 Free PMC article.

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