Topoisomerase II as a target of VM-26 and 4'-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells.
de Jong S, Kooistra AJ, de Vries EG, Mulder NH, Zijlstra JG.
de Jong S, et al. Among authors: de vries eg.
Cancer Res. 1993 Mar 1;53(5):1064-71.
Cancer Res. 1993.
PMID: 8382551
GLC4/ADR cells demonstrated a reduced Topo II activity and no detectable levels of the P-glycoprotein compared to the parental GLC4 cells (S. De Jong et al., Cancer Res., 50: 304-309, 1990). In the present study, the resistance to VM-26 (59.5-fold) and to m-A …
GLC4/ADR cells demonstrated a reduced Topo II activity and no detectable levels of the P-glycoprotein compared to the parental GLC4 cells ( …