Moore LB - Search Results

1

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. Watkins RE, et al. Among authors: moore lb. Biochemistry. 2003 Feb 18;42(6):1430-8. doi: 10.1021/bi0268753. Biochemistry. 2003. PMID: 12578355

2

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Chrencik JE, et al. Among authors: moore lb. Mol Endocrinol. 2005 May;19(5):1125-34. doi: 10.1210/me.2004-0346. Epub 2005 Feb 10. Mol Endocrinol. 2005. PMID: 15705662

3

Human PXR forms a tryptophan zipper-mediated homodimer.

Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Noble SM, et al. Among authors: moore lb. Biochemistry. 2006 Jul 18;45(28):8579-89. doi: 10.1021/bi0602821. Biochemistry. 2006. PMID: 16834332 Free PMC article.

4

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.

Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR. Xue Y, et al. Among authors: moore lb. Mol Endocrinol. 2007 May;21(5):1028-38. doi: 10.1210/me.2006-0323. Epub 2007 Feb 27. Mol Endocrinol. 2007. PMID: 17327420

5

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.

Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. Watkins RE, et al. Among authors: moore lb. Science. 2001 Jun 22;292(5525):2329-33. doi: 10.1126/science.1060762. Epub 2001 Jun 14. Science. 2001. PMID: 11408620

6

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.

Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT. Maglich JM, et al. Among authors: moore lb, moore jt. J Biol Chem. 2003 May 9;278(19):17277-83. doi: 10.1074/jbc.M300138200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12611900 Free article.

7

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.

Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, Moore JT. Moore LB, et al. Among authors: moore jt. Mol Endocrinol. 2002 May;16(5):977-86. doi: 10.1210/mend.16.5.0828. Mol Endocrinol. 2002. PMID: 11981033

8

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates.

Jones SA, Moore LB, Wisely GB, Kliewer SA. Jones SA, et al. Among authors: moore lb. Methods Enzymol. 2002;357:161-70. doi: 10.1016/s0076-6879(02)57675-8. Methods Enzymol. 2002. PMID: 12424907 No abstract available.

9

Functional and structural comparison of PXR and CAR.

Moore JT, Moore LB, Maglich JM, Kliewer SA. Moore JT, et al. Among authors: moore lb. Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8. doi: 10.1016/s0304-4165(02)00481-6. Biochim Biophys Acta. 2003. PMID: 12573482 Review.

10

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT. Jones SA, et al. Among authors: moore lb, moore jt. Mol Endocrinol. 2000 Jan;14(1):27-39. doi: 10.1210/mend.14.1.0409. Mol Endocrinol. 2000. PMID: 10628745

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