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945 results

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Page 1
Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand.
Choi-Sledeski YM, Kearney R, Poli G, Pauls H, Gardner C, Gong Y, Becker M, Davis R, Spada A, Liang G, Chu V, Brown K, Collussi D, Leadley R Jr, Rebello S, Moxey P, Morgan S, Bentley R, Kasiewski C, Maignan S, Guilloteau JP, Mikol V. Choi-Sledeski YM, et al. Among authors: poli g. J Med Chem. 2003 Feb 27;46(5):681-4. doi: 10.1021/jm020384z. J Med Chem. 2003. PMID: 12593648
A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO).
Liang G, Choi-Sledeski YM, Poli G, Chen X, Shum P, Minnich A, Wang Q, Tsay J, Sides K, Cairns J, Stoklosa G, Nieduzak T, Zhao Z, Wang J, Vaz RJ. Liang G, et al. Among authors: poli g. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6721-4. doi: 10.1016/j.bmcl.2010.08.141. Epub 2010 Sep 6. Bioorg Med Chem Lett. 2010. PMID: 20855210
Novel cytokine release inhibitors. Part IV: analogs of podocarpic acid.
He W, Gavai A, Huang FC, Regan J, Hanney B, Poli G, Bruno J, Chan WK, Djuric SW, Yu KT, Zilberstein A. He W, et al. Among authors: poli g. Bioorg Med Chem Lett. 1999 Feb 8;9(3):469-74. doi: 10.1016/s0960-894x(99)00023-2. Bioorg Med Chem Lett. 1999. PMID: 10091704
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity.
Huang FC, Galemmo RA Jr, Poli GB, Learn KS, Morrissette MM, Johnson WH Jr, Dankulich WP, Campbell HF, Carnathan GW, VanInwegen RG. Huang FC, et al. Among authors: poli gb. J Med Chem. 1991 May;34(5):1704-7. doi: 10.1021/jm00109a025. J Med Chem. 1991. PMID: 1851845
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity.
Huang FC, Galemmo RA Jr, Johnson WH Jr, Poli GB, Morrissette MM, Mencel JJ, Warus JD, Campbell HF, Nuss GW, Carnathan GW, et al. Huang FC, et al. Among authors: poli gb. J Med Chem. 1990 Apr;33(4):1194-200. doi: 10.1021/jm00166a017. J Med Chem. 1990. PMID: 2157010
2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors.
Regan J, Bruno J, McGarry D, Poli G, Hanney B, Bower S, Travis J, Sweeney D, Miller B, Souness J, Djuric S. Regan J, et al. Among authors: poli g. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2737-42. doi: 10.1016/s0960-894x(98)00497-1. Bioorg Med Chem Lett. 1998. PMID: 9873613
945 results