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BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.
Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Kim KB, Ciurea AM, Duvic M, Prieto VG, Ullrich SE, Dalby KN, Flores ER, Tsai KY. Vin H, et al. Among authors: dwyer dw. Elife. 2013 Nov 5;2:e00969. doi: 10.7554/eLife.00969. Elife. 2013. PMID: 24192036 Free PMC article.
Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.
Vin H, Ching G, Ojeda SS, Adelmann CH, Chitsazzadeh V, Dwyer DW, Ma H, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Ciurea AM, Duvic M, Busaidy NL, Tannir NM, Tsai KY. Vin H, et al. Among authors: dwyer dw. Mol Cancer Ther. 2014 Jan;13(1):221-9. doi: 10.1158/1535-7163.MCT-13-0561. Epub 2013 Oct 29. Mol Cancer Ther. 2014. PMID: 24170769 Free PMC article.