Boehm JC - Search Results

1

N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors.

Wan Z, Boehm JC, Bower MJ, Kassis S, Lee JC, Zhao B, Adams JL. Wan Z, et al. Among authors: boehm jc. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1191-4. doi: 10.1016/s0960-894x(03)00048-9. Bioorg Med Chem Lett. 2003. PMID: 12643941

2

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase.

Gallagher TF, Seibel GL, Kassis S, Laydon JT, Blumenthal MJ, Lee JC, Lee D, Boehm JC, Fier-Thompson SM, Abt JW, Soreson ME, Smietana JM, Hall RF, Garigipati RS, Bender PE, Erhard KF, Krog AJ, Hofmann GA, Sheldrake PL, McDonnell PC, Kumar S, Young PR, Adams JL. Gallagher TF, et al. Among authors: boehm jc. Bioorg Med Chem. 1997 Jan;5(1):49-64. doi: 10.1016/s0968-0896(96)00212-x. Bioorg Med Chem. 1997. PMID: 9043657

3

Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

Adams JL, Boehm JC, Kassis S, Gorycki PD, Webb EF, Hall R, Sorenson M, Lee JC, Ayrton A, Griswold DE, Gallagher TF. Adams JL, et al. Among authors: boehm jc. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3111-6. doi: 10.1016/s0960-894x(98)00549-6. Bioorg Med Chem Lett. 1998. PMID: 9873686

4

Phenoxypyrimidine inhibitors of p38alpha kinase: synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles.

Boehm JC, Bower MJ, Gallagher TF, Kassis S, Johnson SR, Adams JL. Boehm JC, et al. Bioorg Med Chem Lett. 2001 May 7;11(9):1123-6. doi: 10.1016/s0960-894x(01)00163-9. Bioorg Med Chem Lett. 2001. PMID: 11354358

5

Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity.

Adams JL, Boehm JC, Gallagher TF, Kassis S, Webb EF, Hall R, Sorenson M, Garigipati R, Griswold DE, Lee JC. Adams JL, et al. Among authors: boehm jc. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2867-70. doi: 10.1016/s0960-894x(01)00570-4. Bioorg Med Chem Lett. 2001. PMID: 11597418

6

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases.

Kumar S, Boehm J, Lee JC. Kumar S, et al. Among authors: boehm j. Nat Rev Drug Discov. 2003 Sep;2(9):717-26. doi: 10.1038/nrd1177. Nat Rev Drug Discov. 2003. PMID: 12951578 Review.

7

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL. Boehm JC, et al. J Med Chem. 1996 Sep 27;39(20):3929-37. doi: 10.1021/jm960415o. J Med Chem. 1996. PMID: 8831759

8

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis.

Badger AM, Griswold DE, Kapadia R, Blake S, Swift BA, Hoffman SJ, Stroup GB, Webb E, Rieman DJ, Gowen M, Boehm JC, Adams JL, Lee JC. Badger AM, et al. Among authors: boehm jc. Arthritis Rheum. 2000 Jan;43(1):175-83. doi: 10.1002/1529-0131(200001)43:1<175::AID-ANR22>3.0.CO;2-S. Arthritis Rheum. 2000. PMID: 10643714 Free article.

9

Structural basis of inhibitor selectivity in MAP kinases.

Wang Z, Canagarajah BJ, Boehm JC, Kassisà S, Cobb MH, Young PR, Abdel-Meguid S, Adams JL, Goldsmith EJ. Wang Z, et al. Among authors: boehm jc. Structure. 1998 Sep 15;6(9):1117-28. doi: 10.1016/s0969-2126(98)00113-0. Structure. 1998. PMID: 9753691 Free article.

10

Synthesis of structural analogs of leukotriene B4 and their receptor binding activity.

Kingsbury WD, Pendrak I, Leber JD, Boehm JC, Mallet B, Sarau HM, Foley JJ, Schmidt DB, Daines RA. Kingsbury WD, et al. Among authors: boehm jc. J Med Chem. 1993 Oct 29;36(22):3308-20. doi: 10.1021/jm00074a012. J Med Chem. 1993. PMID: 8230121

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