Lee JC - Search Results

1

N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors.

Wan Z, Boehm JC, Bower MJ, Kassis S, Lee JC, Zhao B, Adams JL. Wan Z, et al. Among authors: lee jc. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1191-4. doi: 10.1016/s0960-894x(03)00048-9. Bioorg Med Chem Lett. 2003. PMID: 12643941

2

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase.

Gallagher TF, Seibel GL, Kassis S, Laydon JT, Blumenthal MJ, Lee JC, Lee D, Boehm JC, Fier-Thompson SM, Abt JW, Soreson ME, Smietana JM, Hall RF, Garigipati RS, Bender PE, Erhard KF, Krog AJ, Hofmann GA, Sheldrake PL, McDonnell PC, Kumar S, Young PR, Adams JL. Gallagher TF, et al. Among authors: lee d, lee jc. Bioorg Med Chem. 1997 Jan;5(1):49-64. doi: 10.1016/s0968-0896(96)00212-x. Bioorg Med Chem. 1997. PMID: 9043657

3

Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

Adams JL, Boehm JC, Kassis S, Gorycki PD, Webb EF, Hall R, Sorenson M, Lee JC, Ayrton A, Griswold DE, Gallagher TF. Adams JL, et al. Among authors: lee jc. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3111-6. doi: 10.1016/s0960-894x(98)00549-6. Bioorg Med Chem Lett. 1998. PMID: 9873686

4

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials.

Lee JC, Kassis S, Kumar S, Badger A, Adams JL. Lee JC, et al. Pharmacol Ther. 1999 May-Jun;82(2-3):389-97. doi: 10.1016/s0163-7258(99)00008-x. Pharmacol Ther. 1999. PMID: 10454214 Review.

5

Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity.

Adams JL, Boehm JC, Gallagher TF, Kassis S, Webb EF, Hall R, Sorenson M, Garigipati R, Griswold DE, Lee JC. Adams JL, et al. Among authors: lee jc. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2867-70. doi: 10.1016/s0960-894x(01)00570-4. Bioorg Med Chem Lett. 2001. PMID: 11597418

6

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases.

Kumar S, Boehm J, Lee JC. Kumar S, et al. Among authors: lee jc. Nat Rev Drug Discov. 2003 Sep;2(9):717-26. doi: 10.1038/nrd1177. Nat Rev Drug Discov. 2003. PMID: 12951578 Review.

7

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL. Boehm JC, et al. Among authors: lee jc. J Med Chem. 1996 Sep 27;39(20):3929-37. doi: 10.1021/jm960415o. J Med Chem. 1996. PMID: 8831759

8

Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site.

Young PR, McLaughlin MM, Kumar S, Kassis S, Doyle ML, McNulty D, Gallagher TF, Fisher S, McDonnell PC, Carr SA, Huddleston MJ, Seibel G, Porter TG, Livi GP, Adams JL, Lee JC. Young PR, et al. Among authors: lee jc. J Biol Chem. 1997 May 2;272(18):12116-21. doi: 10.1074/jbc.272.18.12116. J Biol Chem. 1997. PMID: 9115281 Free article.

9

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket.

Gum RJ, McLaughlin MM, Kumar S, Wang Z, Bower MJ, Lee JC, Adams JL, Livi GP, Goldsmith EJ, Young PR. Gum RJ, et al. Among authors: lee jc. J Biol Chem. 1998 Jun 19;273(25):15605-10. doi: 10.1074/jbc.273.25.15605. J Biol Chem. 1998. PMID: 9624152 Free article.

10

Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase.

Kumar S, Jiang MS, Adams JL, Lee JC. Kumar S, et al. Among authors: lee jc. Biochem Biophys Res Commun. 1999 Oct 5;263(3):825-31. doi: 10.1006/bbrc.1999.1454. Biochem Biophys Res Commun. 1999. PMID: 10512765

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