Beese LS - Search Results

1

Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations.

Johnson SJ, Taylor JS, Beese LS. Johnson SJ, et al. Among authors: beese ls. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3895-900. doi: 10.1073/pnas.0630532100. Epub 2003 Mar 20. Proc Natl Acad Sci U S A. 2003. PMID: 12649320 Free PMC article.

2

Cocrystal structure of an editing complex of Klenow fragment with DNA.

Freemont PS, Friedman JM, Beese LS, Sanderson MR, Steitz TA. Freemont PS, et al. Among authors: beese ls. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8924-8. doi: 10.1073/pnas.85.23.8924. Proc Natl Acad Sci U S A. 1988. PMID: 3194400 Free PMC article.

3

Structure of DNA polymerase I Klenow fragment bound to duplex DNA.

Beese LS, Derbyshire V, Steitz TA. Beese LS, et al. Science. 1993 Apr 16;260(5106):352-5. doi: 10.1126/science.8469987. Science. 1993. PMID: 8469987

4

Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.

Kiefer JR, Mao C, Hansen CJ, Basehore SL, Hogrefe HH, Braman JC, Beese LS. Kiefer JR, et al. Among authors: beese ls. Structure. 1997 Jan 15;5(1):95-108. doi: 10.1016/s0969-2126(97)00169-x. Structure. 1997. PMID: 9016716 Free article.

5

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.

Kiefer JR, Mao C, Braman JC, Beese LS. Kiefer JR, et al. Among authors: beese ls. Nature. 1998 Jan 15;391(6664):304-7. doi: 10.1038/34693. Nature. 1998. PMID: 9440698

6

Crystallization and preliminary diffraction analysis of a hyperthermostable DNA polymerase from a Thermococcus archaeon.

Zhou M, Mao C, Rodriguez AC, Kiefer JR, Kucera RB, Beese LS. Zhou M, et al. Among authors: beese ls. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):994-5. doi: 10.1107/s0907444998001553. Acta Crystallogr D Biol Crystallogr. 1998. PMID: 9757117

7

Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7.

Rodriguez AC, Park HW, Mao C, Beese LS. Rodriguez AC, et al. Among authors: beese ls. J Mol Biol. 2000 Jun 2;299(2):447-62. doi: 10.1006/jmbi.2000.3728. J Mol Biol. 2000. PMID: 10860752

8

The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.

Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS. Long SB, et al. Among authors: beese ls. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12948-53. doi: 10.1073/pnas.241407898. Epub 2001 Oct 30. Proc Natl Acad Sci U S A. 2001. PMID: 11687658 Free PMC article.

9

3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

Bell IM, Gallicchio SN, Abrams M, Beese LS, Beshore DC, Bhimnathwala H, Bogusky MJ, Buser CA, Culberson JC, Davide J, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hamilton KA, Hartman GD, Heimbrook DC, Homnick CF, Huber HE, Huff JR, Kassahun K, Koblan KS, Kohl NE, Lobell RB, Lynch JJ Jr, Robinson R, Rodrigues AD, Taylor JS, Walsh ES, Williams TM, Zartman CB. Bell IM, et al. Among authors: beese ls. J Med Chem. 2002 Jun 6;45(12):2388-409. doi: 10.1021/jm010531d. J Med Chem. 2002. PMID: 12036349

10

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

deSolms SJ, Ciccarone TM, MacTough SC, Shaw AW, Buser CA, Ellis-Hutchings M, Fernandes C, Hamilton KA, Huber HE, Kohl NE, Lobell RB, Robinson RG, Tsou NN, Walsh ES, Graham SL, Beese LS, Taylor JS. deSolms SJ, et al. Among authors: beese ls. J Med Chem. 2003 Jul 3;46(14):2973-84. doi: 10.1021/jm020587n. J Med Chem. 2003. PMID: 12825937

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