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Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions.
Stemerding AM, Köhl J, Pandey MK, Kuipers A, Leusen JH, Boross P, Nederend M, Vidarsson G, Weersink AY, van de Winkel JG, van Kessel KP, van Strijp JA. Stemerding AM, et al. J Immunol. 2013 Jul 1;191(1):353-62. doi: 10.4049/jimmunol.1203243. Epub 2013 Jun 5. J Immunol. 2013. PMID: 23740955
C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases.
Zwarthoff SA, Widmer K, Kuipers A, Strasser J, Ruyken M, Aerts PC, de Haas CJC, Ugurlar D, den Boer MA, Vidarsson G, van Strijp JAG, Gros P, Parren PWHI, van Kessel KPM, Preiner J, Beurskens FJ, Schuurman J, Ricklin D, Rooijakkers SHM. Zwarthoff SA, et al. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2102787118. doi: 10.1073/pnas.2102787118. Proc Natl Acad Sci U S A. 2021. PMID: 34155115 Free PMC article.
Bacteria under stress by complement and coagulation.
Berends ET, Kuipers A, Ravesloot MM, Urbanus RT, Rooijakkers SH. Berends ET, et al. FEMS Microbiol Rev. 2014 Nov;38(6):1146-71. doi: 10.1111/1574-6976.12080. Epub 2014 Sep 3. FEMS Microbiol Rev. 2014. PMID: 25065463 Free article. Review.
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