Takemura H - Search Results

1

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y. Furuta T, et al. Among authors: takemura h. J Biol Chem. 2003 May 30;278(22):20303-12. doi: 10.1074/jbc.M300198200. Epub 2003 Mar 25. J Biol Chem. 2003. PMID: 12660252 Free article.

2

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Furuta T, Hayward RL, Meng LH, Takemura H, Aune GJ, Bonner WM, Aladjem MI, Kohn KW, Pommier Y. Furuta T, et al. Among authors: takemura h. Oncogene. 2006 May 11;25(20):2839-49. doi: 10.1038/sj.onc.1209313. Oncogene. 2006. PMID: 16407843

3

Repair of and checkpoint response to topoisomerase I-mediated DNA damage.

Pommier Y, Redon C, Rao VA, Seiler JA, Sordet O, Takemura H, Antony S, Meng L, Liao Z, Kohlhagen G, Zhang H, Kohn KW. Pommier Y, et al. Among authors: takemura h. Mutat Res. 2003 Nov 27;532(1-2):173-203. doi: 10.1016/j.mrfmmm.2003.08.016. Mutat Res. 2003. PMID: 14643436 Review.

4

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y. Takemura H, et al. J Biol Chem. 2006 Oct 13;281(41):30814-23. doi: 10.1074/jbc.M603747200. Epub 2006 Aug 10. J Biol Chem. 2006. PMID: 16905549 Free article.

5

UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.

Yu Q, La Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y. Yu Q, et al. Among authors: takemura h. Cancer Res. 2002 Oct 15;62(20):5743-8. Cancer Res. 2002. PMID: 12384533

6

Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.

Meng LH, Zhang H, Hayward L, Takemura H, Shao RG, Pommier Y. Meng LH, et al. Among authors: takemura h. Cancer Res. 2004 Dec 15;64(24):9086-92. doi: 10.1158/0008-5472.CAN-04-0313. Cancer Res. 2004. PMID: 15604277

7

Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway.

Yoshida A, Takemura H, Inoue H, Miyashita T, Ueda T. Yoshida A, et al. Among authors: takemura h. Cancer Res. 2006 Jun 1;66(11):5772-80. doi: 10.1158/0008-5472.CAN-05-3916. Cancer Res. 2006. PMID: 16740716

8

Simultaneous treatment with 1-beta-D-arabinofuranosylcytosine and daunorubicin induces cross-resistance to both drugs due to a combination-specific mechanism in HL60 cells.

Takemura H, Urasaki Y, Yoshida A, Fukushima T, Ueda T. Takemura H, et al. Cancer Res. 2001 Jan 1;61(1):172-7. Cancer Res. 2001. PMID: 11196156

9

Idarubicin and idarubicinol are less affected by topoisomerase II-related multidrug resistance than is daunorubicin.

Fukushima T, Inoue H, Takemura H, Kishi S, Yamauchi T, Inai K, Nakayama T, Imamura S, Urasaki Y, Nakamura T, Ueda T. Fukushima T, et al. Among authors: takemura h. Leuk Res. 1998 Jul;22(7):625-9. doi: 10.1016/s0145-2126(98)00060-5. Leuk Res. 1998. PMID: 9680113

10

Dexamethasone-resistant human Pre-B leukemia 697 cell line evolving elevation of intracellular glutathione level: an additional resistance mechanism.

Inoue H, Takemura H, Kawai Y, Yoshida A, Ueda T, Miyashita T. Inoue H, et al. Among authors: takemura h. Jpn J Cancer Res. 2002 May;93(5):582-90. doi: 10.1111/j.1349-7006.2002.tb01294.x. Jpn J Cancer Res. 2002. PMID: 12036455 Free PMC article.

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