Fischer PM - Search Results

1

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.

Wu SY, McNae I, Kontopidis G, McClue SJ, McInnes C, Stewart KJ, Wang S, Zheleva DI, Marriage H, Lane DP, Taylor P, Fischer PM, Walkinshaw MD. Wu SY, et al. Among authors: fischer pm. Structure. 2003 Apr;11(4):399-410. doi: 10.1016/s0969-2126(03)00060-1. Structure. 2003. PMID: 12679018 Free article.

2

Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.

Kontopidis G, Andrews MJ, McInnes C, Cowan A, Powers H, Innes L, Plater A, Griffiths G, Paterson D, Zheleva DI, Lane DP, Green S, Walkinshaw MD, Fischer PM. Kontopidis G, et al. Among authors: fischer pm. Structure. 2003 Dec;11(12):1537-46. doi: 10.1016/j.str.2003.11.006. Structure. 2003. PMID: 14656438 Free article.

3

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

Uhrinova S, Uhrin D, Powers H, Watt K, Zheleva D, Fischer P, McInnes C, Barlow PN. Uhrinova S, et al. J Mol Biol. 2005 Jul 15;350(3):587-98. doi: 10.1016/j.jmb.2005.05.010. J Mol Biol. 2005. PMID: 15953616

4

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine).

McClue SJ, Blake D, Clarke R, Cowan A, Cummings L, Fischer PM, MacKenzie M, Melville J, Stewart K, Wang S, Zhelev N, Zheleva D, Lane DP. McClue SJ, et al. Among authors: fischer pm. Int J Cancer. 2002 Dec 10;102(5):463-8. doi: 10.1002/ijc.10738. Int J Cancer. 2002. PMID: 12432547

5

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.

Wang S, Meades C, Wood G, Osnowski A, Anderson S, Yuill R, Thomas M, Mezna M, Jackson W, Midgley C, Griffiths G, Fleming I, Green S, McNae I, Wu SY, McInnes C, Zheleva D, Walkinshaw MD, Fischer PM. Wang S, et al. Among authors: fischer pm. J Med Chem. 2004 Mar 25;47(7):1662-75. doi: 10.1021/jm0309957. J Med Chem. 2004. PMID: 15027857

6

Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives.

Brown CJ, McNae I, Fischer PM, Walkinshaw MD. Brown CJ, et al. Among authors: fischer pm. J Mol Biol. 2007 Sep 7;372(1):7-15. doi: 10.1016/j.jmb.2007.06.033. Epub 2007 Jun 15. J Mol Biol. 2007. PMID: 17631896 Review.

7

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.

Wang S, Griffiths G, Midgley CA, Barnett AL, Cooper M, Grabarek J, Ingram L, Jackson W, Kontopidis G, McClue SJ, McInnes C, McLachlan J, Meades C, Mezna M, Stuart I, Thomas MP, Zheleva DI, Lane DP, Jackson RC, Glover DM, Blake DG, Fischer PM. Wang S, et al. Among authors: fischer pm. Chem Biol. 2010 Oct 29;17(10):1111-21. doi: 10.1016/j.chembiol.2010.07.016. Chem Biol. 2010. PMID: 21035734

8

Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics.

Fischer PM, Lane DP. Fischer PM, et al. Curr Med Chem. 2000 Dec;7(12):1213-45. doi: 10.2174/0929867003374048. Curr Med Chem. 2000. PMID: 11032968

9

Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.

McInnes C, Andrews MJ, Zheleva DI, Lane DP, Fischer PM. McInnes C, et al. Among authors: fischer pm. Curr Med Chem Anticancer Agents. 2003 Jan;3(1):57-69. doi: 10.2174/1568011033353506. Curr Med Chem Anticancer Agents. 2003. PMID: 12678915 Review.

10

Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.

McInnes C, Wang S, Anderson S, O'Boyle J, Jackson W, Kontopidis G, Meades C, Mezna M, Thomas M, Wood G, Lane DP, Fischer PM. McInnes C, et al. Among authors: fischer pm. Chem Biol. 2004 Apr;11(4):525-34. doi: 10.1016/j.chembiol.2004.03.022. Chem Biol. 2004. PMID: 15123247

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

200 results

Search Page

Filters