Wang S - Search Results

1

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.

Wu SY, McNae I, Kontopidis G, McClue SJ, McInnes C, Stewart KJ, Wang S, Zheleva DI, Marriage H, Lane DP, Taylor P, Fischer PM, Walkinshaw MD. Wu SY, et al. Among authors: wang s. Structure. 2003 Apr;11(4):399-410. doi: 10.1016/s0969-2126(03)00060-1. Structure. 2003. PMID: 12679018 Free article.

2

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine).

McClue SJ, Blake D, Clarke R, Cowan A, Cummings L, Fischer PM, MacKenzie M, Melville J, Stewart K, Wang S, Zhelev N, Zheleva D, Lane DP. McClue SJ, et al. Among authors: wang s. Int J Cancer. 2002 Dec 10;102(5):463-8. doi: 10.1002/ijc.10738. Int J Cancer. 2002. PMID: 12432547

3

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.

Wang S, Meades C, Wood G, Osnowski A, Anderson S, Yuill R, Thomas M, Mezna M, Jackson W, Midgley C, Griffiths G, Fleming I, Green S, McNae I, Wu SY, McInnes C, Zheleva D, Walkinshaw MD, Fischer PM. Wang S, et al. J Med Chem. 2004 Mar 25;47(7):1662-75. doi: 10.1021/jm0309957. J Med Chem. 2004. PMID: 15027857

4

Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.

McInnes C, Wang S, Anderson S, O'Boyle J, Jackson W, Kontopidis G, Meades C, Mezna M, Thomas M, Wood G, Lane DP, Fischer PM. McInnes C, et al. Among authors: wang s. Chem Biol. 2004 Apr;11(4):525-34. doi: 10.1016/j.chembiol.2004.03.022. Chem Biol. 2004. PMID: 15123247

5

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.

Wang S, Griffiths G, Midgley CA, Barnett AL, Cooper M, Grabarek J, Ingram L, Jackson W, Kontopidis G, McClue SJ, McInnes C, McLachlan J, Meades C, Mezna M, Stuart I, Thomas MP, Zheleva DI, Lane DP, Jackson RC, Glover DM, Blake DG, Fischer PM. Wang S, et al. Chem Biol. 2010 Oct 29;17(10):1111-21. doi: 10.1016/j.chembiol.2010.07.016. Chem Biol. 2010. PMID: 21035734

6

Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.

Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM. Kontopidis G, et al. Among authors: wang s. Chem Biol. 2006 Feb;13(2):201-11. doi: 10.1016/j.chembiol.2005.11.011. Chem Biol. 2006. PMID: 16492568

7

Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors.

McIntyre NA, McInnes C, Griffiths G, Barnett AL, Kontopidis G, Slawin AM, Jackson W, Thomas M, Zheleva DI, Wang S, Blake DG, Westwood NJ, Fischer PM. McIntyre NA, et al. Among authors: wang s. J Med Chem. 2010 Mar 11;53(5):2136-45. doi: 10.1021/jm901660c. J Med Chem. 2010. PMID: 20146435

8

Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.

Wang S, Midgley CA, Scaërou F, Grabarek JB, Griffiths G, Jackson W, Kontopidis G, McClue SJ, McInnes C, Meades C, Mezna M, Plater A, Stuart I, Thomas MP, Wood G, Clarke RG, Blake DG, Zheleva DI, Lane DP, Jackson RC, Glover DM, Fischer PM. Wang S, et al. J Med Chem. 2010 Jun 10;53(11):4367-78. doi: 10.1021/jm901913s. J Med Chem. 2010. PMID: 20462263

9

Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors.

Wang S, Wood G, Meades C, Griffiths G, Midgley C, McNae I, McInnes C, Anderson S, Jackson W, Mezna M, Yuill R, Walkinshaw M, Fischer PM. Wang S, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4237-40. doi: 10.1016/j.bmcl.2004.06.012. Bioorg Med Chem Lett. 2004. PMID: 15261277

10

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.

Liu X, Shi S, Lam F, Pepper C, Fischer PM, Wang S. Liu X, et al. Among authors: wang s. Int J Cancer. 2012 Mar 1;130(5):1216-26. doi: 10.1002/ijc.26127. Epub 2011 Jun 21. Int J Cancer. 2012. PMID: 21484792

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