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Diversity of mechanism-based pharmacodynamic models.
Mager DE, Wyska E, Jusko WJ. Mager DE, et al. Among authors: wyska e. Drug Metab Dispos. 2003 May;31(5):510-8. doi: 10.1124/dmd.31.5.510. Drug Metab Dispos. 2003. PMID: 12695336 Review.
KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain.
Waszkielewicz A, Marona H, Pańczyk-Straszak K, Filipek B, Rapacz A, Sałat K, Kubacka M, Cios A, Fedak F, Walczak M, Hubicka U, Kwiecień A, Żuromska-Witek B, Szafrański PW, Koczurkiewicz-Adamczyk P, Pękala E, Przejczowska-Pomierny K, Pociecha K, Wyska E. Waszkielewicz A, et al. Among authors: wyska e. Pharmacol Rep. 2023 Feb;75(1):128-165. doi: 10.1007/s43440-022-00431-7. Epub 2022 Nov 19. Pharmacol Rep. 2023. PMID: 36401763 Free PMC article.
TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice.
Doboszewska U, Socała K, Pieróg M, Nieoczym D, Sawicki J, Szafarz M, Gawel K, Rafało-Ulińska A, Sajnóg A, Wyska E, Esguerra CV, Szewczyk B, Maćkowiak M, Barałkiewicz D, Mlyniec K, Nowak G, Sowa I, Wlaź P. Doboszewska U, et al. Among authors: wyska e. Cell Mol Life Sci. 2023 Apr 25;80(5):133. doi: 10.1007/s00018-023-04766-z. Cell Mol Life Sci. 2023. PMID: 37185787 Free PMC article.
Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties.
Siwek A, Marcinkowska M, Głuch-Lutwin M, Mordyl B, Wolak M, Jastrzębska-Więsek M, Wilczyńska-Zawal N, Wyska E, Szafrańska K, Karcz T, Ostrowska O, Bucki A, Kołaczkowski M. Siwek A, et al. Among authors: wyska e. Eur J Med Chem. 2024 Sep 5;275:116601. doi: 10.1016/j.ejmech.2024.116601. Epub 2024 Jun 14. Eur J Med Chem. 2024. PMID: 38901106
Inhaled pan-phosphodiesterase inhibitors ameliorate ovalbumin-induced airway inflammation and remodeling in murine model of allergic asthma.
Wójcik-Pszczoła K, Pociecha K, Chłoń-Rzepa G, Zadrożna M, Nowak B, Plutecka H, Koczurkiewicz-Adamczyk P, Przejczowska-Pomierny K, Pękala E, Gosens R, Wyska E. Wójcik-Pszczoła K, et al. Among authors: wyska e. Int Immunopharmacol. 2023 Jun;119:110264. doi: 10.1016/j.intimp.2023.110264. Epub 2023 May 7. Int Immunopharmacol. 2023. PMID: 37159965 Free article.
The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition.
Domin H, Konieczny J, Cieślik P, Pochwat B, Wyska E, Szafarz M, Lenda T, Biała D, Gąsior Ł, Śmiałowska M, Szewczyk B. Domin H, et al. Among authors: wyska e. Behav Brain Res. 2024 Feb 4;457:114729. doi: 10.1016/j.bbr.2023.114729. Epub 2023 Oct 21. Behav Brain Res. 2024. PMID: 37871655
In silico and in vitro ADME-Tox analysis and in vivo pharmacokinetic study of representative pan-PDE inhibitors from the group of 7,8-disubstituted derivatives of 1,3-dimethyl-7H-purine-2,6-dione.
Wójcik-Pszczoła K, Szafarz M, Pociecha K, Słoczyńska K, Piska K, Koczurkiewicz-Adamczyk P, Kocot N, Chłoń-Rzepa G, Pękala E, Wyska E. Wójcik-Pszczoła K, et al. Among authors: wyska e. Toxicol Appl Pharmacol. 2022 Dec 15;457:116318. doi: 10.1016/j.taap.2022.116318. Epub 2022 Nov 19. Toxicol Appl Pharmacol. 2022. PMID: 36414119
109 results