Le XF - Search Results

1

The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition.

Le XF, Claret FX, Lammayot A, Tian L, Deshpande D, LaPushin R, Tari AM, Bast RC Jr. Le XF, et al. J Biol Chem. 2003 Jun 27;278(26):23441-50. doi: 10.1074/jbc.M300848200. Epub 2003 Apr 16. J Biol Chem. 2003. PMID: 12700233 Free article.

2

Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.

Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr. Le XF, et al. J Biol Chem. 2005 Jan 21;280(3):2092-104. doi: 10.1074/jbc.M403080200. Epub 2004 Oct 25. J Biol Chem. 2005. PMID: 15504738 Free article.

3

HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways.

Le XF, Pruefer F, Bast RC Jr. Le XF, et al. Cell Cycle. 2005 Jan;4(1):87-95. doi: 10.4161/cc.4.1.1360. Epub 2005 Jan 10. Cell Cycle. 2005. PMID: 15611642 Review.

4

Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells.

Le XF, Arachchige-Don AS, Mao W, Horne MC, Bast RC Jr. Le XF, et al. Mol Cancer Ther. 2007 Nov;6(11):2843-57. doi: 10.1158/1535-7163.MCT-07-0109. Mol Cancer Ther. 2007. PMID: 18025271

5

Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway.

Bao JJ, Le XF, Wang RY, Yuan J, Wang L, Atkinson EN, LaPushin R, Andreeff M, Fang B, Yu Y, Bast RC Jr. Bao JJ, et al. Among authors: le xf. Cancer Res. 2002 Dec 15;62(24):7264-72. Cancer Res. 2002. PMID: 12499268

6

Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.

Le XF, Hittelman WN, Liu J, McWatters A, Li C, Mills GB, Bast RC Jr. Le XF, et al. Oncogene. 2003 Jan 30;22(4):484-97. doi: 10.1038/sj.onc.1206175. Oncogene. 2003. PMID: 12555062

7

Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway.

Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC Jr. Le XF, et al. Cell Cycle. 2006 Aug;5(15):1654-61. doi: 10.4161/cc.5.15.3007. Epub 2006 Aug 1. Cell Cycle. 2006. PMID: 16861913

8

Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2.

Le XF, Mao W, Lu C, Thornton A, Heymach JV, Sood AK, Bast RC Jr. Le XF, et al. Cell Cycle. 2008 Dec;7(23):3747-58. doi: 10.4161/cc.7.23.7212. Epub 2008 Dec 16. Cell Cycle. 2008. PMID: 19029832 Free PMC article.

9

Src family kinases and paclitaxel sensitivity.

Le XF, Bast RC Jr. Le XF, et al. Cancer Biol Ther. 2011 Aug 15;12(4):260-9. doi: 10.4161/cbt.12.4.16430. Epub 2011 Aug 15. Cancer Biol Ther. 2011. PMID: 21646863 Free PMC article. Review.

10

The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.

Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC Jr. Le XF, et al. J Natl Cancer Inst. 2011 Sep 21;103(18):1403-22. doi: 10.1093/jnci/djr280. Epub 2011 Aug 2. J Natl Cancer Inst. 2011. PMID: 21813412 Free PMC article.

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