Leurs R - Search Results

1

Improgan antinociception does not require neuronal histamine or histamine receptors.

Izadi Mobarakeh J, Nalwalk JW, Watanabe T, Sakurada S, Hoffman M, Leurs R, Timmerman H, Silos-Santiago I, Yanai K, Hough LB. Izadi Mobarakeh J, et al. Among authors: leurs r. Brain Res. 2003 Jun 6;974(1-2):146-52. doi: 10.1016/s0006-8993(03)02572-1. Brain Res. 2003. PMID: 12742632

2

Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats.

Huang YW, Hu WW, Chen Z, Zhang LS, Shen HQ, Timmerman H, Leurs R, Yanai K. Huang YW, et al. Among authors: leurs r. Behav Brain Res. 2004 May 5;151(1-2):287-93. doi: 10.1016/j.bbr.2003.09.002. Behav Brain Res. 2004. PMID: 15084444

3

Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.

Bannoura MD, Nalwalk JW, Tang Y, Carlile M, Leurs R, Menge WM, Timmerman H, Hough LB. Bannoura MD, et al. Among authors: leurs r. Brain Res. 1998 Dec 14;814(1-2):218-21. doi: 10.1016/s0006-8993(98)01024-5. Brain Res. 1998. PMID: 9838126

4

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.

Hough LB, Nalwalk JW, Chen Y, Schuller A, Zhu Y, Zhang J, Menge WM, Leurs R, Timmerman H, Pintar JE. Hough LB, et al. Among authors: leurs r. Brain Res. 2000 Oct 13;880(1-2):102-8. doi: 10.1016/s0006-8993(00)02776-1. Brain Res. 2000. PMID: 11032994

5

A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic.

Svokos K, Nalwalk JW, Leurs R, Menge WM, Timmerman H, Hough LB. Svokos K, et al. Among authors: leurs r. Brain Res. 2001 Dec 27;923(1-2):12-9. doi: 10.1016/s0006-8993(01)03191-2. Brain Res. 2001. PMID: 11743967

6

Activation of brain stem nuclei by improgan, a non-opioid analgesic.

Nalwalk JW, Svokos K, Taraschenko O, Leurs R, Timmerman H, Hough LB. Nalwalk JW, et al. Among authors: leurs r. Brain Res. 2004 Sep 24;1021(2):248-55. doi: 10.1016/j.brainres.2004.06.066. Brain Res. 2004. PMID: 15342273

7

Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic.

Hough LB, de Esch IJ, Janssen E, Phillips J, Svokos K, Kern B, Trachler J, Abood ME, Leurs R, Nalwalk JW. Hough LB, et al. Among authors: leurs r. Neuropharmacology. 2006 Sep;51(3):447-56. doi: 10.1016/j.neuropharm.2006.04.003. Epub 2006 Jun 23. Neuropharmacology. 2006. PMID: 16806300

8

Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively.

Cannon KE, Leurs R, Hough LB. Cannon KE, et al. Among authors: leurs r. Pharmacol Biochem Behav. 2007 Nov;88(1):122-9. doi: 10.1016/j.pbb.2007.07.014. Epub 2007 Jul 25. Pharmacol Biochem Behav. 2007. PMID: 17719621 Free PMC article.

9

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.

Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X. Hough LB, et al. Among authors: leurs r. Pain. 2011 Apr;152(4):878-887. doi: 10.1016/j.pain.2011.01.001. Pain. 2011. PMID: 21316152 Free PMC article.

10

Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.

Yokoyama H, Onodera K, Maeyama K, Sakurai E, Iinuma K, Leurs R, Timmerman H, Watanabe T. Yokoyama H, et al. Among authors: leurs r. Eur J Pharmacol. 1994 Jul 21;260(1):23-8. doi: 10.1016/0014-2999(94)90005-1. Eur J Pharmacol. 1994. PMID: 7957622

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