Dean BJ - Search Results

1

Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets.

Huskey SE, Dean BJ, Bakhtiar R, Sanchez RI, Tattersall FD, Rycroft W, Hargreaves R, Watt AP, Chicchi GG, Keohane C, Hora DF, Chiu SH. Huskey SE, et al. Among authors: dean bj. Drug Metab Dispos. 2003 Jun;31(6):785-91. doi: 10.1124/dmd.31.6.785. Drug Metab Dispos. 2003. PMID: 12756213

2

Substance P receptor antagonist I: conversion of phosphoramidate prodrug after i.v. administration to rats and dogs.

Huskey SE, Luffer-Atlas D, Dean BJ, McGowan EM, Feeney WP, Chiu SH. Huskey SE, et al. Among authors: dean bj. Drug Metab Dispos. 1999 Nov;27(11):1367-73. Drug Metab Dispos. 1999. PMID: 10534323

3

Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs.

Hale JJ, Mills SG, MacCoss M, Dorn CP, Finke PE, Budhu RJ, Reamer RA, Huskey SE, Luffer-Atlas D, Dean BJ, McGowan EM, Feeney WP, Chiu SH, Cascieri MA, Chicchi GG, Kurtz MM, Sadowski S, Ber E, Tattersall FD, Rupniak NM, Williams AR, Rycroft W, Hargreaves R, Metzger JM, MacIntyre DE. Hale JJ, et al. Among authors: dean bj. J Med Chem. 2000 Mar 23;43(6):1234-41. doi: 10.1021/jm990617v. J Med Chem. 2000. PMID: 10737756

4

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH. Huskey SE, et al. Among authors: dean bj. Drug Metab Dispos. 2004 Feb;32(2):246-58. doi: 10.1124/dmd.32.2.246. Drug Metab Dispos. 2004. PMID: 14744948

5

Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans.

Dean BJ, Chang S, Silva Elipe MV, Xia YQ, Braun M, Soli E, Zhao Y, Franklin RB, Karanam B. Dean BJ, et al. Drug Metab Dispos. 2007 Feb;35(2):283-92. doi: 10.1124/dmd.106.011551. Epub 2006 Nov 28. Drug Metab Dispos. 2007. PMID: 17132765

6

Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humans.

Karanam B, Madeira M, Bradley S, Wenning L, Desai R, Soli E, Schenk D, Jones A, Dean B, Doss G, Garrett G, Crumley T, Nirula A, Lai E. Karanam B, et al. Drug Metab Dispos. 2007 Jul;35(7):1196-202. doi: 10.1124/dmd.107.014696. Epub 2007 Apr 12. Drug Metab Dispos. 2007. PMID: 17431030 Clinical Trial.

7

The pharmacokinetics and disposition of MK-0524, a Prosglandin D2 Receptor 1 antagonist, in rats, dogs and monkeys.

Chang SW, Reddy V, Pereira T, Dean BJ, Xia YQ, Seto C, Franklin RB, Karanam BV. Chang SW, et al. Among authors: dean bj. Xenobiotica. 2007 May;37(5):514-33. doi: 10.1080/00498250601175565. Xenobiotica. 2007. PMID: 17523054

8

The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor.

Takahashi RH, Malhi V, Liederer BM, Cho S, Deng Y, Dean B, Nugteren J, Yost E, Al-Sayah MA, Sane R, Kshirsagar S, Ma S, Musib L. Takahashi RH, et al. Drug Metab Dispos. 2023 Oct;51(10):1332-1341. doi: 10.1124/dmd.122.001175. Epub 2023 Jul 31. Drug Metab Dispos. 2023. PMID: 37524543

9

A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry.

Graham RA, Lum BL, Morrison G, Chang I, Jorga K, Dean B, Shin YG, Yue Q, Mulder T, Malhi V, Xie M, Low JA, Hop CE. Graham RA, et al. Drug Metab Dispos. 2011 Aug;39(8):1460-7. doi: 10.1124/dmd.111.039339. Epub 2011 May 20. Drug Metab Dispos. 2011. PMID: 21602311 Clinical Trial.

10

Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-Sparing PI3K Inhibitor in Rats, Dogs, and Humans.

Ma S, Cho S, Sahasranaman S, Zhao W, Pang J, Ding X, Dean B, Wang B, Hsu JY, Ware J, Salphati L. Ma S, et al. Drug Metab Dispos. 2023 Apr;51(4):436-450. doi: 10.1124/dmd.122.001096. Epub 2023 Jan 9. Drug Metab Dispos. 2023. PMID: 36623882

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