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Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
Most P, Remppis A, Pleger ST, Löffler E, Ehlermann P, Bernotat J, Kleuss C, Heierhorst J, Ruiz P, Witt H, Karczewski P, Mao L, Rockman HA, Duncan SJ, Katus HA, Koch WJ. Most P, et al. Among authors: pleger st. J Biol Chem. 2003 Sep 5;278(36):33809-17. doi: 10.1074/jbc.M301788200. Epub 2003 May 30. J Biol Chem. 2003. PMID: 12777394 Free article.
The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers.
Most P, Remppis A, Weber C, Bernotat J, Ehlermann P, Pleger ST, Kirsch W, Weber M, Uttenweiler D, Smith GL, Katus HA, Fink RH. Most P, et al. Among authors: pleger st. J Biol Chem. 2003 Jul 18;278(29):26356-64. doi: 10.1074/jbc.M303338200. Epub 2003 Apr 28. J Biol Chem. 2003. PMID: 12721284 Free article.
Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2).
Most P, Boerries M, Eicher C, Schweda C, Ehlermann P, Pleger ST, Loeffler E, Koch WJ, Katus HA, Schoenenberger CA, Remppis A. Most P, et al. Among authors: pleger st. J Biol Chem. 2003 Nov 28;278(48):48404-12. doi: 10.1074/jbc.M308587200. Epub 2003 Sep 6. J Biol Chem. 2003. PMID: 12960148 Free article.
S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts.
Remppis A, Pleger ST, Most P, Lindenkamp J, Ehlermann P, Schweda C, Löffler E, Weichenhan D, Zimmermann W, Eschenhagen T, Koch WJ, Katus HA. Remppis A, et al. Among authors: pleger st. J Gene Med. 2004 Apr;6(4):387-94. doi: 10.1002/jgm.513. J Gene Med. 2004. PMID: 15079813
S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.
Pleger ST, Remppis A, Heidt B, Völkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, Müller OJ, Eckhart AD, Katus HA, Koch WJ, Most P. Pleger ST, et al. Mol Ther. 2005 Dec;12(6):1120-9. doi: 10.1016/j.ymthe.2005.08.002. Epub 2005 Sep 15. Mol Ther. 2005. PMID: 16168714 Free article.
S100A1: a regulator of myocardial contractility.
Most P, Bernotat J, Ehlermann P, Pleger ST, Reppel M, Börries M, Niroomand F, Pieske B, Janssen PM, Eschenhagen T, Karczewski P, Smith GL, Koch WJ, Katus HA, Remppis A. Most P, et al. Among authors: pleger st. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13889-94. doi: 10.1073/pnas.241393598. Proc Natl Acad Sci U S A. 2001. PMID: 11717446 Free PMC article.
Hope for a broken heart?
Most P, Eicher C, Völkers M, Pleger ST, Katus HA. Most P, et al. Among authors: pleger st. Trends Biotechnol. 2004 Oct;22(10):487-9. doi: 10.1016/j.tibtech.2004.08.004. Trends Biotechnol. 2004. PMID: 15450736
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
Most P, Pleger ST, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ. Most P, et al. Among authors: pleger st. J Clin Invest. 2004 Dec;114(11):1550-63. doi: 10.1172/JCI21454. J Clin Invest. 2004. PMID: 15578088 Free PMC article.
84 results