Barrett MP - Search Results

1

Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.

Dardonville C, Rinaldi E, Hanau S, Barrett MP, Brun R, Gilbert IH. Dardonville C, et al. Among authors: barrett mp. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. doi: 10.1016/s0968-0896(03)00191-3. Bioorg Med Chem. 2003. PMID: 12818683

2

6-Phosphogluconate dehydrogenase from Trypanosoma brucei. Kinetic analysis and inhibition by trypanocidal drugs.

Hanau S, Rippa M, Bertelli M, Dallocchio F, Barrett MP. Hanau S, et al. Among authors: barrett mp. Eur J Biochem. 1996 Sep 15;240(3):592-9. doi: 10.1111/j.1432-1033.1996.0592h.x. Eur J Biochem. 1996. PMID: 8856059 Free article.

3

The cross-linking by o-phthalaldehyde of two amino acid residues at the active site of 6-phosphogluconate dehydrogenase.

Giovannini PP, Rippa M, Dallocchio F, Tetaud M, Barrett MP, Hanau S. Giovannini PP, et al. Among authors: barrett mp. Biochem Mol Biol Int. 1997 Sep;43(1):153-60. doi: 10.1080/15216549700203921. Biochem Mol Biol Int. 1997. PMID: 9315293

4

A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues.

Phillips C, Dohnalek J, Gover S, Barrett MP, Adams MJ. Phillips C, et al. Among authors: barrett mp. J Mol Biol. 1998 Sep 25;282(3):667-81. doi: 10.1006/jmbi.1998.2059. J Mol Biol. 1998. PMID: 9737929

5

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

Tye CK, Kasinathan G, Barrett MP, Brun R, Doyle VE, Fairlamb AH, Weaver R, Gilbert IH. Tye CK, et al. Among authors: barrett mp. Bioorg Med Chem Lett. 1998 Apr 7;8(7):811-6. doi: 10.1016/s0960-894x(98)00095-x. Bioorg Med Chem Lett. 1998. PMID: 9871546

6

6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species.

Rippa M, Giovannini PP, Barrett MP, Dallocchio F, Hanau S. Rippa M, et al. Among authors: barrett mp. Biochim Biophys Acta. 1998 Dec 8;1429(1):83-92. doi: 10.1016/s0167-4838(98)00222-2. Biochim Biophys Acta. 1998. PMID: 9920387

7

6-Phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme.

Tetaud E, Hanau S, Wells JM, Le Page RW, Adams MJ, Arkison S, Barrett MP. Tetaud E, et al. Among authors: barrett mp. Biochem J. 1999 Feb 15;338 ( Pt 1)(Pt 1):55-60. Biochem J. 1999. PMID: 9931298 Free PMC article.

8

Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.

Bertelli M, El-Bastawissy E, Knaggs MH, Barrett MP, Hanau S, Gilbert IH. Bertelli M, et al. Among authors: barrett mp. J Comput Aided Mol Des. 2001 May;15(5):465-75. doi: 10.1023/a:1011196508214. J Comput Aided Mol Des. 2001. PMID: 11394739

9

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.

Klenke B, Stewart M, Barrett MP, Brun R, Gilbert IH. Klenke B, et al. Among authors: barrett mp. J Med Chem. 2001 Oct 11;44(21):3440-52. doi: 10.1021/jm010854+. J Med Chem. 2001. PMID: 11585449

10

Perspectives for new drugs against trypanosomiasis and leishmaniasis.

Barrett MP, Gilbert IH. Barrett MP, et al. Curr Top Med Chem. 2002 May;2(5):471-82. doi: 10.2174/1568026024607427. Curr Top Med Chem. 2002. PMID: 11966468 Review.

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