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Page 1
Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model.
Suleymanov OD, Szalony JA, Salyers AK, LaChance RM, Parlow JJ, South MS, Wood RS, Nicholson NS. Suleymanov OD, et al. Among authors: lachance rm. J Pharmacol Exp Ther. 2003 Sep;306(3):1115-21. doi: 10.1124/jpet.103.052779. Epub 2003 Jun 26. J Pharmacol Exp Ther. 2003. PMID: 12829728
Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
Parlow JJ, Case BL, Dice TA, Fenton RL, Hayes MJ, Jones DE, Neumann WL, Wood RS, Lachance RM, Girard TJ, Nicholson NS, Clare M, Stegeman RA, Stevens AM, Stallings WC, Kurumbail RG, South MS. Parlow JJ, et al. Among authors: lachance rm. J Med Chem. 2003 Sep 11;46(19):4050-62. doi: 10.1021/jm030131l. J Med Chem. 2003. PMID: 12954058
Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time.
Szalony JA, Suleymanov OD, Salyers AK, Panzer-Knodle SG, Blom JD, LaChance RM, Case BL, Parlow JJ, South MS, Wood RS, Nicholson NS. Szalony JA, et al. Among authors: lachance rm. Thromb Res. 2003;112(3):167-74. doi: 10.1016/j.thromres.2003.10.017. Thromb Res. 2003. PMID: 14967414
Part II: piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.
Parlow JJ, Burney MW, Case BL, Girard TJ, Hall KA, Harris PK, Hiebsch RR, Huff RM, Lachance RM, Mischke DA, Rapp SR, Woerndle RS, Ennis MD. Parlow JJ, et al. Among authors: lachance rm. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1388-94. doi: 10.1016/j.bmcl.2009.12.110. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20097563
34 results