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778 results

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Page 1
Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia.
Lynch JJ Jr, Houle MS, Stump GL, Wallace AA, Gilberto DB, Jahansouz H, Smith GR, Tebben AJ, Liverton NJ, Selnick HG, Claremon DA, Billman GE. Lynch JJ Jr, et al. Among authors: smith gr. Circulation. 1999 Nov 2;100(18):1917-22. doi: 10.1161/01.cir.100.18.1917. Circulation. 1999. PMID: 10545437
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.
Selnick HG, Liverton NJ, Baldwin JJ, Butcher JW, Claremon DA, Elliott JM, Freidinger RM, King SA, Libby BE, McIntyre CJ, Pribush DA, Remy DC, Smith GR, Tebben AJ, Jurkiewicz NK, Lynch JJ, Salata JJ, Sanguinetti MC, Siegl PK, Slaughter DE, Vyas K. Selnick HG, et al. Among authors: smith gr. J Med Chem. 1997 Nov 21;40(24):3865-8. doi: 10.1021/jm970517u. J Med Chem. 1997. PMID: 9397166 No abstract available.
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Liverton NJ, Butcher JW, Claiborne CF, Claremon DA, Libby BE, Nguyen KT, Pitzenberger SM, Selnick HG, Smith GR, Tebben A, Vacca JP, Varga SL, Agarwal L, Dancheck K, Forsyth AJ, Fletcher DS, Frantz B, Hanlon WA, Harper CF, Hofsess SJ, Kostura M, Lin J, Luell S, O'Neill EA, O'Keefe SJ, et al. Liverton NJ, et al. Among authors: smith gr. J Med Chem. 1999 Jun 17;42(12):2180-90. doi: 10.1021/jm9805236. J Med Chem. 1999. PMID: 10377223
An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division.
Dalgliesh C, Aldalaqan S, Atallah C, Best A, Scott E, Ehrmann I, Merces G, Mannion J, Badurova B, Sandher R, Illing Y, Wirth B, Wells S, Codner G, Teboul L, Smith GR, Hedley A, Herbert M, de Rooij DG, Miles C, Reynard LN, Elliott DJ. Dalgliesh C, et al. Among authors: smith gr. EMBO J. 2025 Jan 2. doi: 10.1038/s44318-024-00344-6. Online ahead of print. EMBO J. 2025. PMID: 39748121 Free article.
Molecular basis of resistance to leaf spot disease in oil palm.
Wibowo CS, Susilo R, Ernawan R, Apriyanto A, Alshaharni MO, Smith GR, Gatehouse AMR, Edwards MG. Wibowo CS, et al. Among authors: smith gr. Front Plant Sci. 2024 Dec 9;15:1458346. doi: 10.3389/fpls.2024.1458346. eCollection 2024. Front Plant Sci. 2024. PMID: 39717734 Free PMC article.
Identification of Inhibitors of Chikungunya virus nsP2 ATPase.
Navarro H, Scott JE, Smith GR, Ghiabi P, Gibson E, Loppnau P, Harding RJ, Hossain MA, Bose MR, Pearce KH, Merten EM, Willson TM, Brown PJ. Navarro H, et al. Among authors: smith gr. bioRxiv [Preprint]. 2024 Dec 6:2024.12.02.625520. doi: 10.1101/2024.12.02.625520. bioRxiv. 2024. PMID: 39677726 Free PMC article. Preprint.
Debunking the dogma that RecBCD nuclease destroys phage.
Zheng C, Furukawa C, Liu J, Sankaran S, Lin H, Munugeti N, Wang M, Smith GR. Zheng C, et al. Among authors: smith gr. Genetics. 2024 Nov 28:iyae199. doi: 10.1093/genetics/iyae199. Online ahead of print. Genetics. 2024. PMID: 39605281
778 results