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8-Oxoguanine rearranges the active site of human topoisomerase I.
Lesher DT, Pommier Y, Stewart L, Redinbo MR. Lesher DT, et al. Among authors: stewart l. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12102-7. doi: 10.1073/pnas.192282699. Epub 2002 Sep 3. Proc Natl Acad Sci U S A. 2002. PMID: 12209008 Free PMC article.
The mechanism of topoisomerase I poisoning by a camptothecin analog.
Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L. Staker BL, et al. Among authors: stewart l. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92. doi: 10.1073/pnas.242259599. Epub 2002 Nov 8. Proc Natl Acad Sci U S A. 2002. PMID: 12426403 Free PMC article.
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB. Staker BL, et al. Among authors: stewart l. J Med Chem. 2005 Apr 7;48(7):2336-45. doi: 10.1021/jm049146p. J Med Chem. 2005. PMID: 15801827
Annu. Rev. Biochem. 2001, 70, 369-413. Stewart, L.; et al. Science 1998, 729, 1534-1541.) We report the X-ray crystal structures of the human top1-DNA complex bound with camptothecin and representative members of the indenoisoquinoline and indolocarbazole classes of …
Annu. Rev. Biochem. 2001, 70, 369-413. Stewart, L.; et al. Science 1998, 729, 1534-1541.) We report the X-ray crystal structur …
DcpS as a therapeutic target for spinal muscular atrophy.
Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney ME. Singh J, et al. Among authors: stewart l. ACS Chem Biol. 2008 Nov 21;3(11):711-22. doi: 10.1021/cb800120t. ACS Chem Biol. 2008. PMID: 18839960 Free PMC article.
1,671 results