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Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.
Cheng Y, Zhang F, Rano TA, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Rutkowski CA, Lin JH, Jin L, Emini EA, Chapman KT, Tata JR. Cheng Y, et al. Among authors: rutkowski ca. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2419-22. doi: 10.1016/s0960-894x(02)00424-9. Bioorg Med Chem Lett. 2002. PMID: 12161147
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
Lu Z, Bohn J, Rano T, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR. Lu Z, et al. Among authors: rutkowski ca. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5311-4. doi: 10.1016/j.bmcl.2005.08.072. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203148
15 results