Baxter A - Search Results

1

Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists.

Baxter A, Bennion C, Bent J, Boden K, Brough S, Cooper A, Kinchin E, Kindon N, McInally T, Mortimore M, Roberts B, Unitt J. Baxter A, et al. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2625-8. doi: 10.1016/s0960-894x(03)00561-4. Bioorg Med Chem Lett. 2003. PMID: 12873480

2

Novel P2X7 receptor antagonists.

Alcaraz L, Baxter A, Bent J, Bowers K, Braddock M, Cladingboel D, Donald D, Fagura M, Furber M, Laurent C, Lawson M, Mortimore M, McCormick M, Roberts N, Robertson M. Alcaraz L, et al. Among authors: baxter a. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4043-6. doi: 10.1016/j.bmcl.2003.08.033. Bioorg Med Chem Lett. 2003. PMID: 14592504

3

Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists.

Baxter A, Bent J, Bowers K, Braddock M, Brough S, Fagura M, Lawson M, McInally T, Mortimore M, Robertson M, Weaver R, Webborn P. Baxter A, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4047-50. doi: 10.1016/j.bmcl.2003.08.034. Bioorg Med Chem Lett. 2003. PMID: 14592505

4

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors.

Baxter A, Brough S, Cooper A, Floettmann E, Foster S, Harding C, Kettle J, McInally T, Martin C, Mobbs M, Needham M, Newham P, Paine S, St-Gallay S, Salter S, Unitt J, Xue Y. Baxter A, et al. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22. doi: 10.1016/j.bmcl.2004.03.058. Bioorg Med Chem Lett. 2004. PMID: 15125939

5

Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists.

Baxter A, Cooper A, Kinchin E, Moakes K, Unitt J, Wallace A. Baxter A, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):960-3. doi: 10.1016/j.bmcl.2005.10.091. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16297626

6

Discovery of small molecule human C5a receptor antagonists.

Sanganee HJ, Baxter A, Barber S, Brown AJ, Grice D, Hunt F, King S, Laughton D, Pairaudeau G, Thong B, Weaver R, Unitt J. Sanganee HJ, et al. Among authors: baxter a. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1143-7. doi: 10.1016/j.bmcl.2008.12.104. Epub 2008 Dec 31. Bioorg Med Chem Lett. 2009. PMID: 19171482

7

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.

Kindon N, Andrews G, Baxter A, Cheshire D, Hemsley P, Johnson T, Liu YZ, McGinnity D, McHale M, Mete A, Reuberson J, Roberts B, Steele J, Teobald B, Unitt J, Vaughan D, Walters I, Stocks MJ. Kindon N, et al. Among authors: baxter a. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. doi: 10.1021/acsmedchemlett.7b00315. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947948 Free PMC article.

8

Discovery of small molecule human FPR1 receptor antagonists.

Unitt J, Fagura M, Phillips T, King S, Perry M, Morley A, MacDonald C, Weaver R, Christie J, Barber S, Mohammed R, Paul M, Cook A, Baxter A. Unitt J, et al. Among authors: baxter a. Bioorg Med Chem Lett. 2011 May 15;21(10):2991-7. doi: 10.1016/j.bmcl.2011.03.049. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21486695

9

Non-covalent inhibitors of rhinovirus 3C protease.

Baxter A, Chambers M, Edfeldt F, Edman K, Freeman A, Johansson C, King S, Morley A, Petersen J, Rawlins P, Spadola L, Thong B, Van de Poël H, Williams N. Baxter A, et al. Bioorg Med Chem Lett. 2011 Jan 15;21(2):777-80. doi: 10.1016/j.bmcl.2010.11.110. Epub 2010 Nov 26. Bioorg Med Chem Lett. 2011. PMID: 21183345

10

(R)-2-(3-mercapto-2(S)-methyl-1-oxo-propoxy)-3-(methylthio)propanoic acid, the first ultra-short-acting angiotensin converting enzyme inhibitor.

Baxter AJ, Carr RD, Eyley SC, Fraser-Rae L, Hallam C, Harper ST, Hurved PA, King SJ, Meghani P. Baxter AJ, et al. J Med Chem. 1992 Oct 2;35(20):3718-20. doi: 10.1021/jm00098a019. J Med Chem. 1992. PMID: 1433185 No abstract available.

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