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Page 1
Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain.
Davies SJ, Ayscough AP, Beckett RP, Bragg RA, Clements JM, Doel S, Grew C, Launchbury SB, Perkins GM, Pratt LM, Smith HK, Spavold ZM, Thomas SW, Todd RS, Whittaker M. Davies SJ, et al. Among authors: ayscough ap. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2709-13. doi: 10.1016/s0960-894x(03)00532-8. Bioorg Med Chem Lett. 2003. PMID: 12873499
Peptidomimetic inhibitors of bacterial peptide deformylase.
East SP, Ayscough A, Toogood-Johnson I, Taylor S, Thomas W. East SP, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4032-5. doi: 10.1016/j.bmcl.2011.04.132. Epub 2011 May 11. Bioorg Med Chem Lett. 2011. PMID: 21621999
Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist.
Dickson L, Teall M, Chevalier E, Cheung T, Liwicki GM, Mack S, Stephenson A, White K, Fosbeary R, Harrison DC, Brice NL, Doyle K, Ciccocioppo R, Wu C, Almond S, Patel TR, Mitchell P, Barnes M, Ayscough AP, Dawson LA, Carlton M, Bürli RW. Dickson L, et al. Among authors: ayscough ap. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. doi: 10.1021/acsmedchemlett.2c00529. eCollection 2023 Apr 13. ACS Med Chem Lett. 2023. PMID: 37077399 Free PMC article.
Assessing molecular scaffolds for CNS drug discovery.
Mayol-Llinàs J, Nelson A, Farnaby W, Ayscough A. Mayol-Llinàs J, et al. Drug Discov Today. 2017 Jul;22(7):965-969. doi: 10.1016/j.drudis.2017.01.008. Epub 2017 Jan 20. Drug Discov Today. 2017. PMID: 28111331 Free article.