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Signal transduction by several KIT juxtamembrane domain mutations.
Casteran N, De Sepulveda P, Beslu N, Aoubala M, Letard S, Lecocq E, Rottapel R, Dubreuil P. Casteran N, et al. Among authors: dubreuil p. Oncogene. 2003 Jul 24;22(30):4710-22. doi: 10.1038/sj.onc.1206587. Oncogene. 2003. PMID: 12879016
KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.
Chaix A, Arcangeli ML, Lopez S, Voisset E, Yang Y, Vita M, Letard S, Audebert S, Finetti P, Birnbaum D, Bertucci F, Aurrand-Lions M, Dubreuil P, De Sepulveda P. Chaix A, et al. Among authors: dubreuil p. Oncogene. 2014 Feb 13;33(7):872-81. doi: 10.1038/onc.2013.12. Epub 2013 Feb 18. Oncogene. 2014. PMID: 23416972
Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations.
Yang Y, Létard S, Borge L, Chaix A, Hanssens K, Lopez S, Vita M, Finetti P, Birnbaum D, Bertucci F, Gomez S, de Sepulveda P, Dubreuil P. Yang Y, et al. Among authors: dubreuil p. Blood. 2010 Aug 19;116(7):1114-23. doi: 10.1182/blood-2009-06-226027. Epub 2010 May 18. Blood. 2010. PMID: 20484085 Free article.
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.
Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Castéran N, Borge L, Hajem B, Lermet A, Sippl W, Voisset E, Arock M, Auclair C, Leventhal PS, Mansfield CD, Moussy A, Hermine O. Dubreuil P, et al. PLoS One. 2009 Sep 30;4(9):e7258. doi: 10.1371/journal.pone.0007258. PLoS One. 2009. PMID: 19789626 Free PMC article.
339 results