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Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.
Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Sanchez C, et al. Among authors: piccardi n. Osteoarthritis Cartilage. 2005 Nov;13(11):979-87. doi: 10.1016/j.joca.2005.03.008. Osteoarthritis Cartilage. 2005. PMID: 16243232 Free article.
Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis.
Cortial D, Gouttenoire J, Rousseau CF, Ronzière MC, Piccardi N, Msika P, Herbage D, Mallein-Gerin F, Freyria AM. Cortial D, et al. Among authors: piccardi n. Osteoarthritis Cartilage. 2006 Jul;14(7):631-40. doi: 10.1016/j.joca.2006.01.008. Epub 2006 Mar 9. Osteoarthritis Cartilage. 2006. PMID: 16527498 Free article.
Effects of a vegetable extract from Lupinus albus (LU105) on the production of matrix metalloproteinases (MMP1, MMP2, MMP9) and tissue inhibitor of metalloproteinases (TIMP1, TIMP2) by human gingival fibroblasts in culture.
Gaultier F, Foucault-Bertaud A, Lamy E, Ejeil AL, Dridi SM, Piccardi N, Piccirilli A, Msika P, Godeau G, Gogly B. Gaultier F, et al. Among authors: piccardi n. Clin Oral Investig. 2003 Dec;7(4):198-205. doi: 10.1007/s00784-003-0210-y. Epub 2003 Jun 7. Clin Oral Investig. 2003. PMID: 12802622
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