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Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl protein degradation.
Buton X, Mamdouh Z, Ghosh R, Du H, Kuriakose G, Beatini N, Grabowski GA, Maxfield FR, Tabas I. Buton X, et al. Among authors: tabas i. J Biol Chem. 1999 Nov 5;274(45):32112-21. doi: 10.1074/jbc.274.45.32112. J Biol Chem. 1999. PMID: 10542246 Free article.
Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function.
Marathe S, Miranda SR, Devlin C, Johns A, Kuriakose G, Williams KJ, Schuchman EH, Tabas I. Marathe S, et al. Among authors: tabas i. Hum Mol Genet. 2000 Aug 12;9(13):1967-76. doi: 10.1093/hmg/9.13.1967. Hum Mol Genet. 2000. PMID: 10942425
Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response.
Zhang D, Tang W, Yao PM, Yang C, Xie B, Jackowski S, Tabas I. Zhang D, et al. Among authors: tabas i. J Biol Chem. 2000 Nov 10;275(45):35368-76. doi: 10.1074/jbc.M007099200. J Biol Chem. 2000. PMID: 10944538 Free article.
292 results