Shin DH - Search Results

1

N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.

Jeong LS, Jin DZ, Kim HO, Shin DH, Moon HR, Gunaga P, Chun MW, Kim YC, Melman N, Gao ZG, Jacobson KA. Jeong LS, et al. Among authors: shin dh. J Med Chem. 2003 Aug 28;46(18):3775-7. doi: 10.1021/jm034098e. J Med Chem. 2003. PMID: 12930138

2

Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.

Jeong LS, Moon HR, Park JG, Shin DH, Choi WJ, Lee KM, Kim HO, Chun MW, Kim HD, Kim JH. Jeong LS, et al. Among authors: shin dh. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):589-92. doi: 10.1081/NCN-120021961. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565234

3

Preparative and stereoselective synthesis of the versatile intermediate for carbocyclic nucleosides: effects of the bulky protecting groups to enforce facial selectivity.

Choi WJ, Moon HR, Kim HO, Yoo BN, Lee JA, Shin DH, Jeong LS. Choi WJ, et al. Among authors: shin dh. J Org Chem. 2004 Apr 2;69(7):2634-6. doi: 10.1021/jo0356762. J Org Chem. 2004. PMID: 15049678

4

Recent advances in 4'-thionucleosides as potential antiviral and antitumor agents.

Gunaga P, Moon HR, Choi WJ, Shin DH, Park JG, Jeong LS. Gunaga P, et al. Among authors: shin dh. Curr Med Chem. 2004 Oct;11(19):2585-637. doi: 10.2174/0929867043364478. Curr Med Chem. 2004. PMID: 15544465 Review.

5

D-4'-thioadenosine derivatives as highly potent and selective agonists at the human A3 adenosine receptor.

Lee HW, Shin DH, Jeong JY, Kim HO, Chun MW, Melman N, Gao ZG, Jacobson KA, Jeong LS. Lee HW, et al. Among authors: shin dh. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):607-9. doi: 10.1081/NCN-200061827. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247997

6

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.

Jeong LS, Lee HW, Jacobson KA, Kim HO, Shin DH, Lee JA, Gao ZG, Lu C, Duong HT, Gunaga P, Lee SK, Jin DZ, Chun MW, Moon HR. Jeong LS, et al. Among authors: shin dh. J Med Chem. 2006 Jan 12;49(1):273-81. doi: 10.1021/jm050595e. J Med Chem. 2006. PMID: 16392812

7

Design, synthesis, and biological activity of N6-substituted-4'-thioadenosines at the human A3 adenosine receptor.

Jeong LS, Lee HW, Kim HO, Jung JY, Gao ZG, Duong HT, Rao S, Jacobson KA, Shin DH, Lee JA, Gunaga P, Lee SK, Jin DZ, Chun MW, Moon HR. Jeong LS, et al. Among authors: shin dh. Bioorg Med Chem. 2006 Jul 15;14(14):4718-30. doi: 10.1016/j.bmc.2006.03.030. Epub 2006 Apr 5. Bioorg Med Chem. 2006. PMID: 16603368

8

A novel adenosine analog, thio-Cl-IB-MECA, induces G0/G1 cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells.

Lee EJ, Min HY, Chung HJ, Park EJ, Shin DH, Jeong LS, Lee SK. Lee EJ, et al. Among authors: shin dh. Biochem Pharmacol. 2005 Sep 15;70(6):918-24. doi: 10.1016/j.bcp.2005.06.017. Biochem Pharmacol. 2005. PMID: 16051194

On this line, we recently found that a novel adenosine analog, 2-chloro-N6-(3-iodobenzyl)-4'-thioadenosine-5'-N-methyluronamide (thio-Cl-IB-MECA) was a potent human A3AR agonist, and is superior to a known agonist Cl-IB-MECA [Jeong LS, Jin DZ, Kim HO, Shin DH, Moon …

On this line, we recently found that a novel adenosine analog, 2-chloro-N6-(3-iodobenzyl)-4'-thioadenosine-5'-N-methyluronamide (thio-Cl-IB- …

9

Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells.

Kim SJ, Min HY, Chung HJ, Park EJ, Hong JY, Kang YJ, Shin DH, Jeong LS, Lee SK. Kim SJ, et al. Among authors: shin dh. Cancer Lett. 2008 Jun 18;264(2):309-15. doi: 10.1016/j.canlet.2008.01.037. Epub 2008 Mar 5. Cancer Lett. 2008. PMID: 18321638

10

Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.

Gao ZG, Jeong LS, Moon HR, Kim HO, Choi WJ, Shin DH, Elhalem E, Comin MJ, Melman N, Mamedova L, Gross AS, Rodriguez JB, Jacobson KA. Gao ZG, et al. Among authors: shin dh. Biochem Pharmacol. 2004 Mar 1;67(5):893-901. doi: 10.1016/j.bcp.2003.10.006. Biochem Pharmacol. 2004. PMID: 15104242 Free PMC article.

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