Munier-Lehmann H - Search Results

1

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3045-8. doi: 10.1016/s0960-894x(03)00643-7. Bioorg Med Chem Lett. 2003. PMID: 12941330

2

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents.

Jian Y, Hulpia F, Risseeuw MDP, Forbes HE, Munier-Lehmann H, Caljon G, Boshoff HIM, Van Calenbergh S. Jian Y, et al. Eur J Med Chem. 2020 Sep 1;201:112450. doi: 10.1016/j.ejmech.2020.112450. Epub 2020 Jun 12. Eur J Med Chem. 2020. PMID: 32623208 Free PMC article.

3

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents.

Jian Y, Merceron R, De Munck S, Forbes HE, Hulpia F, Risseeuw MDP, Van Hecke K, Savvides SN, Munier-Lehmann H, Boshoff HIM, Van Calenbergh S. Jian Y, et al. Eur J Med Chem. 2020 Nov 15;206:112659. doi: 10.1016/j.ejmech.2020.112659. Epub 2020 Jul 24. Eur J Med Chem. 2020. PMID: 32823003 Free PMC article.

4

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.

Song L, Merceron R, Hulpia F, Lucía A, Gracia B, Jian Y, Risseeuw MDP, Verstraelen T, Cos P, Aínsa JA, Boshoff HI, Munier-Lehmann H, Savvides SN, Van Calenbergh S. Song L, et al. Eur J Med Chem. 2021 Dec 5;225:113784. doi: 10.1016/j.ejmech.2021.113784. Epub 2021 Aug 18. Eur J Med Chem. 2021. PMID: 34450493 Free PMC article.

5

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2695-8. doi: 10.1016/s0960-894x(02)00551-6. Bioorg Med Chem Lett. 2002. PMID: 12217356

6

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.

Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M. Haouz A, et al. J Biol Chem. 2003 Feb 14;278(7):4963-71. doi: 10.1074/jbc.M209630200. Epub 2002 Nov 25. J Biol Chem. 2003. PMID: 12454011 Free article.

7

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. J Med Chem. 2003 Aug 28;46(18):3811-21. doi: 10.1021/jm021108n. J Med Chem. 2003. PMID: 12930144 Free article.

8

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Vanheusden V, Munier-Lehmann H, Froeyen M, Busson R, Rozenski J, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. J Med Chem. 2004 Dec 2;47(25):6187-94. doi: 10.1021/jm040847w. J Med Chem. 2004. PMID: 15566289

9

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.

Van Daele I, Munier-Lehmann H, Hendrickx PM, Marchal G, Chavarot P, Froeyen M, Qing L, Martins JC, Van Calenbergh S. Van Daele I, et al. ChemMedChem. 2006 Oct;1(10):1081-90. doi: 10.1002/cmdc.200600028. ChemMedChem. 2006. PMID: 16921580

10

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.

Van Daele I, Munier-Lehmann H, Froeyen M, Balzarini J, Van Calenbergh S. Van Daele I, et al. J Med Chem. 2007 Nov 1;50(22):5281-92. doi: 10.1021/jm0706158. Epub 2007 Oct 2. J Med Chem. 2007. PMID: 17910427

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