Brown JR - Search Results

1

Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.

Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Müller R, Brown JR, Hennet T, Esko JD, Aroian RV. Griffitts JS, et al. Among authors: brown jr. J Biol Chem. 2003 Nov 14;278(46):45594-602. doi: 10.1074/jbc.M308142200. Epub 2003 Aug 27. J Biol Chem. 2003. PMID: 12944392 Free article.

2

Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).

Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD. Bai X, et al. Among authors: brown jr. J Biol Chem. 2001 Dec 21;276(51):48189-95. doi: 10.1074/jbc.M107339200. Epub 2001 Sep 10. J Biol Chem. 2001. PMID: 11551958 Free article.

3

The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase.

Hwang HY, Olson SK, Brown JR, Esko JD, Horvitz HR. Hwang HY, et al. Among authors: brown jr. J Biol Chem. 2003 Apr 4;278(14):11735-8. doi: 10.1074/jbc.C200518200. Epub 2003 Feb 12. J Biol Chem. 2003. PMID: 12584198 Free article.

4

Expression patterns of alpha 2,3-sialyltransferases and alpha 1,3-fucosyltransferases determine the mode of sialyl Lewis X inhibition by disaccharide decoys.

Brown JR, Fuster MM, Whisenant T, Esko JD. Brown JR, et al. J Biol Chem. 2003 Jun 27;278(26):23352-9. doi: 10.1074/jbc.M303093200. Epub 2003 Apr 9. J Biol Chem. 2003. PMID: 12686549 Free article.

5

Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to L-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase.

Brown JR, Nishimura Y, Esko JD. Brown JR, et al. Bioorg Med Chem Lett. 2006 Feb;16(3):532-6. doi: 10.1016/j.bmcl.2005.10.055. Epub 2005 Nov 4. Bioorg Med Chem Lett. 2006. PMID: 16275065

6

Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.

Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK, Esko JD. Brown JR, et al. J Biol Chem. 2009 Feb 20;284(8):4952-9. doi: 10.1074/jbc.M805782200. Epub 2008 Dec 23. J Biol Chem. 2009. PMID: 19106107 Free PMC article.

7

Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance.

Stanford KI, Wang L, Castagnola J, Song D, Bishop JR, Brown JR, Lawrence R, Bai X, Habuchi H, Tanaka M, Cardoso WV, Kimata K, Esko JD. Stanford KI, et al. Among authors: brown jr. J Biol Chem. 2010 Jan 1;285(1):286-94. doi: 10.1074/jbc.M109.063701. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889634 Free PMC article.

8

Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins.

Wang L, Brown JR, Varki A, Esko JD. Wang L, et al. Among authors: brown jr. J Clin Invest. 2002 Jul;110(1):127-36. doi: 10.1172/JCI14996. J Clin Invest. 2002. PMID: 12093896 Free PMC article.

9

A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination.

Brown JR, Fuster MM, Li R, Varki N, Glass CA, Esko JD. Brown JR, et al. Clin Cancer Res. 2006 May 1;12(9):2894-901. doi: 10.1158/1078-0432.CCR-05-2745. Clin Cancer Res. 2006. PMID: 16675586

10

Glycan antagonists and inhibitors: a fount for drug discovery.

Brown JR, Crawford BE, Esko JD. Brown JR, et al. Crit Rev Biochem Mol Biol. 2007 Nov-Dec;42(6):481-515. doi: 10.1080/10409230701751611. Crit Rev Biochem Mol Biol. 2007. PMID: 18066955 Review.

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