Klein BD - Search Results

1

Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.

Isoherranen N, White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M. Isoherranen N, et al. Among authors: klein bd. Pharm Res. 2003 Aug;20(8):1293-301. doi: 10.1023/a:1025069519218. Pharm Res. 2003. PMID: 12948028

2

Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models.

White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. White HS, et al. Among authors: klein bd. Neurotherapeutics. 2009 Apr;6(2):372-80. doi: 10.1016/j.nurt.2009.01.001. Neurotherapeutics. 2009. PMID: 19332332 Free PMC article.

3

Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics.

Metcalf CS, Klein BD, McDougle DR, Zhang L, Kaufmann D, Bulaj G, White HS. Metcalf CS, et al. Among authors: klein bd. Epilepsia. 2017 Feb;58(2):239-246. doi: 10.1111/epi.13647. Epub 2017 Jan 18. Epilepsia. 2017. PMID: 28098336 Free PMC article.

4

Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy.

Barton ME, Klein BD, Wolf HH, White HS. Barton ME, et al. Among authors: klein bd. Epilepsy Res. 2001 Dec;47(3):217-27. doi: 10.1016/s0920-1211(01)00302-3. Epilepsy Res. 2001. PMID: 11738929

5

Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities.

Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. Green BR, et al. J Pept Sci. 2010 Sep;16(9):486-95. doi: 10.1002/psc.1266. J Pept Sci. 2010. PMID: 20645434

6

c-Fos immunohistochemical mapping of the audiogenic seizure network and tonotopic neuronal hyperexcitability in the inferior colliculus of the Frings mouse.

Klein BD, Fu YH, Ptacek LJ, White HS. Klein BD, et al. Epilepsy Res. 2004 Nov;62(1):13-25. doi: 10.1016/j.eplepsyres.2004.06.007. Epilepsy Res. 2004. PMID: 15519128

7

Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics.

Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Zhang L, et al. Among authors: klein bd. Mol Pharm. 2013 Feb 4;10(2):574-85. doi: 10.1021/mp300236v. Epub 2013 Jan 15. Mol Pharm. 2013. PMID: 23259957

8

Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms.

Jequier Gygax M, Klein BD, White HS, Kim M, Galanopoulou AS. Jequier Gygax M, et al. Among authors: klein bd. Epilepsy Res. 2014 Jan;108(1):98-108. doi: 10.1016/j.eplepsyres.2013.10.015. Epub 2013 Oct 28. Epilepsy Res. 2014. PMID: 24252685 Free PMC article.

9

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.

Metcalf CS, Klein BD, Smith MD, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Metcalf CS, et al. Among authors: klein bd. Epilepsia. 2018 Mar;59(3):724-735. doi: 10.1111/epi.14005. Epub 2018 Jan 23. Epilepsia. 2018. PMID: 29360159

10

Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes.

Klein BD, White HS, Callahan KS. Klein BD, et al. Neurochem Int. 2000 Apr;36(4-5):441-9. doi: 10.1016/s0197-0186(99)00147-3. Neurochem Int. 2000. PMID: 10733012

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