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Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.
Jin XL, Chandrakanthan V, Morgan HD, O'Neill C. Jin XL, et al. Biol Reprod. 2009 Feb;80(2):286-94. doi: 10.1095/biolreprod.108.070102. Epub 2008 Oct 15. Biol Reprod. 2009. Corrected and republished in: Biol Reprod. 2009 Jul;81(1):234-42. doi: 10.1095/biolreprod.109.078444 PMID: 18923161 Free PMC article. Corrected and republished.
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