Somoza JR - Search Results

1

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.

Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA. Somoza JR, et al. Structure. 2003 Sep;11(9):1123-31. doi: 10.1016/s0969-2126(03)00148-5. Structure. 2003. PMID: 12962630 Free article.

2

The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.

Somoza JR, Palmer JT, Ho JD. Somoza JR, et al. J Mol Biol. 2002 Sep 20;322(3):559-68. doi: 10.1016/s0022-2836(02)00780-5. J Mol Biol. 2002. PMID: 12225749

3

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.

Somoza JR, Skene RJ, Katz BA, Mol C, Ho JD, Jennings AJ, Luong C, Arvai A, Buggy JJ, Chi E, Tang J, Sang BC, Verner E, Wynands R, Leahy EM, Dougan DR, Snell G, Navre M, Knuth MW, Swanson RV, McRee DE, Tari LW. Somoza JR, et al. Structure. 2004 Jul;12(7):1325-34. doi: 10.1016/j.str.2004.04.012. Structure. 2004. PMID: 15242608 Free article.

4

Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor.

Ho JD, Meltser Y, Buggy JJ, Palmer JT, Elrod KC, Chan H, Mortara KD, Somoza JR. Ho JD, et al. Among authors: somoza jr. Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2187-90. doi: 10.1107/s0907444902017535. Epub 2002 Nov 23. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 12454497

5

Peptide ketobenzoxazole inhibitors bound to cathepsin K.

McGrath ME, Sprengeler PA, Hill CM, Martichonok V, Cheung H, Somoza JR, Palmer JT, Janc JW. McGrath ME, et al. Among authors: somoza jr. Biochemistry. 2003 Dec 30;42(51):15018-28. doi: 10.1021/bi035041x. Biochemistry. 2003. PMID: 14690410

6

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Katz BA, et al. Among authors: somoza jr. J Mol Biol. 2004 Nov 19;344(2):527-47. doi: 10.1016/j.jmb.2004.09.032. J Mol Biol. 2004. PMID: 15522303

7

Structure-guided design of peptide-based tryptase inhibitors.

McGrath ME, Sprengeler PA, Hirschbein B, Somoza JR, Lehoux I, Janc JW, Gjerstad E, Graupe M, Estiarte A, Venkataramani C, Liu Y, Yee R, Ho JD, Green MJ, Lee CS, Liu L, Tai V, Spencer J, Sperandio D, Katz BA. McGrath ME, et al. Among authors: somoza jr. Biochemistry. 2006 May 16;45(19):5964-73. doi: 10.1021/bi060173m. Biochemistry. 2006. PMID: 16681368

8

Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.

Lee CS, Liu W, Sprengeler PA, Somoza JR, Janc JW, Sperandio D, Spencer JR, Green MJ, McGrath ME. Lee CS, et al. Among authors: somoza jr. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4036-40. doi: 10.1016/j.bmcl.2006.05.009. Epub 2006 May 22. Bioorg Med Chem Lett. 2006. PMID: 16714109

9

Crystal structure of human cathepsin V.

Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME. Somoza JR, et al. Biochemistry. 2000 Oct 17;39(41):12543-51. doi: 10.1021/bi000951p. Biochemistry. 2000. PMID: 11027133

10

Crystal structure of human cathepsin S.

McGrath ME, Palmer JT, Brömme D, Somoza JR. McGrath ME, et al. Among authors: somoza jr. Protein Sci. 1998 Jun;7(6):1294-302. doi: 10.1002/pro.5560070604. Protein Sci. 1998. PMID: 9655332 Free PMC article.

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