Sprengeler PA - Search Results

1

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.

Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA. Somoza JR, et al. Among authors: sprengeler pa. Structure. 2003 Sep;11(9):1123-31. doi: 10.1016/s0969-2126(03)00148-5. Structure. 2003. PMID: 12962630 Free article.

2

Contribution of multicentered short hydrogen bond arrays to potency of active site-directed serine protease inhibitors.

Katz BA, Spencer JR, Elrod K, Luong C, Mackman RL, Rice M, Sprengeler PA, Allen D, Janc J. Katz BA, et al. Among authors: sprengeler pa. J Am Chem Soc. 2002 Oct 2;124(39):11657-68. doi: 10.1021/ja020082m. J Am Chem Soc. 2002. PMID: 12296731

3

Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.

Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW. Katz BA, et al. Among authors: sprengeler pa. J Mol Biol. 2003 May 23;329(1):93-120. doi: 10.1016/s0022-2836(03)00399-1. J Mol Biol. 2003. PMID: 12742021

4

Peptide ketobenzoxazole inhibitors bound to cathepsin K.

McGrath ME, Sprengeler PA, Hill CM, Martichonok V, Cheung H, Somoza JR, Palmer JT, Janc JW. McGrath ME, et al. Among authors: sprengeler pa. Biochemistry. 2003 Dec 30;42(51):15018-28. doi: 10.1021/bi035041x. Biochemistry. 2003. PMID: 14690410

5

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Katz BA, et al. Among authors: sprengeler pa. J Mol Biol. 2004 Nov 19;344(2):527-47. doi: 10.1016/j.jmb.2004.09.032. J Mol Biol. 2004. PMID: 15522303

6

Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.

Tang J, Yu CL, Williams SR, Springman E, Jeffery D, Sprengeler PA, Estevez A, Sampang J, Shrader W, Spencer J, Young W, McGrath M, Katz BA. Tang J, et al. Among authors: sprengeler pa. J Biol Chem. 2005 Dec 9;280(49):41077-89. doi: 10.1074/jbc.M506766200. Epub 2005 Sep 30. J Biol Chem. 2005. PMID: 16199530 Free article.

7

Small molecule inhibitors of plasma kallikrein.

Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. Young WB, et al. Among authors: sprengeler pa. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2034-6. doi: 10.1016/j.bmcl.2005.12.060. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413183

8

Structure-guided design of peptide-based tryptase inhibitors.

McGrath ME, Sprengeler PA, Hirschbein B, Somoza JR, Lehoux I, Janc JW, Gjerstad E, Graupe M, Estiarte A, Venkataramani C, Liu Y, Yee R, Ho JD, Green MJ, Lee CS, Liu L, Tai V, Spencer J, Sperandio D, Katz BA. McGrath ME, et al. Among authors: sprengeler pa. Biochemistry. 2006 May 16;45(19):5964-73. doi: 10.1021/bi060173m. Biochemistry. 2006. PMID: 16681368

9

Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.

Lee CS, Liu W, Sprengeler PA, Somoza JR, Janc JW, Sperandio D, Spencer JR, Green MJ, McGrath ME. Lee CS, et al. Among authors: sprengeler pa. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4036-40. doi: 10.1016/j.bmcl.2006.05.009. Epub 2006 May 22. Bioorg Med Chem Lett. 2006. PMID: 16714109

10

Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.

Sperandio D, Tai VW, Lohman J, Hirschbein B, Mendonca R, Lee CS, Spencer JR, Janc J, Nguyen M, Beltman J, Sprengeler P, Scheerens H, Lin T, Liu L, Gadre A, Kellogg A, Green MJ, McGrath ME. Sperandio D, et al. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4085-9. doi: 10.1016/j.bmcl.2006.04.088. Epub 2006 May 24. Bioorg Med Chem Lett. 2006. PMID: 16725321

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