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54 results

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Page 1
Identification of novel isoform-selective inhibitors within class I histone deacetylases.
Hu E, Dul E, Sung CM, Chen Z, Kirkpatrick R, Zhang GF, Johanson K, Liu R, Lago A, Hofmann G, Macarron R, de los Frailes M, Perez P, Krawiec J, Winkler J, Jaye M. Hu E, et al. Among authors: krawiec j. J Pharmacol Exp Ther. 2003 Nov;307(2):720-8. doi: 10.1124/jpet.103.055541. Epub 2003 Sep 15. J Pharmacol Exp Ther. 2003. PMID: 12975486
Endothelial lipase and HDL metabolism.
Jaye M, Krawiec J. Jaye M, et al. Among authors: krawiec j. Curr Opin Lipidol. 2004 Apr;15(2):183-9. doi: 10.1097/00041433-200404000-00011. Curr Opin Lipidol. 2004. PMID: 15017361 Review.
Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.
Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA, Sha D, Suarez DP, Murphy DJ, Harpel MR, Manas ES, McNulty DE, Annan RS, Matico RE, Schwartz BK, Trill JJ, Sweitzer TD, Wang DY, Keller PM, Krawiec JA, Jaye MC. Goodman KB, et al. Among authors: krawiec ja. Bioorg Med Chem Lett. 2009 Jan 1;19(1):27-30. doi: 10.1016/j.bmcl.2008.11.033. Epub 2008 Nov 14. Bioorg Med Chem Lett. 2009. PMID: 19058966
Synthetic LXR agonists increase LDL in CETP species.
Groot PH, Pearce NJ, Yates JW, Stocker C, Sauermelch C, Doe CP, Willette RN, Olzinski A, Peters T, d'Epagnier D, Morasco KO, Krawiec JA, Webb CL, Aravindhan K, Jucker B, Burgert M, Ma C, Marino JP, Collins JL, Macphee CH, Thompson SK, Jaye M. Groot PH, et al. Among authors: krawiec ja. J Lipid Res. 2005 Oct;46(10):2182-91. doi: 10.1194/jlr.M500116-JLR200. Epub 2005 Jul 16. J Lipid Res. 2005. PMID: 16024916 Free article.
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Jaye MC, et al. Among authors: krawiec ja. J Med Chem. 2005 Aug 25;48(17):5419-22. doi: 10.1021/jm050532w. J Med Chem. 2005. PMID: 16107141
A high-throughput screen for endothelial lipase using HDL as substrate.
Keller PM, Rust T, Murphy DJ, Matico R, Trill JJ, Krawiec JA, Jurewicz A, Jaye M, Harpel M, Thrall S, Schwartz B. Keller PM, et al. Among authors: krawiec ja. J Biomol Screen. 2008 Jul;13(6):468-75. doi: 10.1177/1087057108319738. Epub 2008 Jun 19. J Biomol Screen. 2008. PMID: 18566479
A novel endothelial-derived lipase that modulates HDL metabolism.
Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ. Jaye M, et al. Among authors: krawiec j. Nat Genet. 1999 Apr;21(4):424-8. doi: 10.1038/7766. Nat Genet. 1999. PMID: 10192396
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