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Page 1
Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate.
Guerassimov A, Zhang Y, Banerjee S, Cartman A, Leroux JY, Rosenberg LC, Esdaile J, Fitzcharles MA, Poole AR. Guerassimov A, et al. Among authors: cartman a. Arthritis Rheum. 1998 Jun;41(6):1019-25. doi: 10.1002/1529-0131(199806)41:6<1019::AID-ART8>3.0.CO;2-X. Arthritis Rheum. 1998. PMID: 9627011
Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes.
Zhang Y, Guerassimov A, Leroux JY, Cartman A, Webber C, Lalic R, de Miguel E, Rosenberg LC, Poole AR. Zhang Y, et al. Among authors: cartman a. J Clin Invest. 1998 Apr 15;101(8):1678-86. doi: 10.1172/JCI1666. J Clin Invest. 1998. PMID: 9541498 Free PMC article.
Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.
Leroux JY, Guerassimov A, Cartman A, Delaunay N, Webber C, Rosenberg LC, Banerjee S, Poole AR. Leroux JY, et al. Among authors: cartman a. J Clin Invest. 1996 Feb 1;97(3):621-32. doi: 10.1172/JCI118458. J Clin Invest. 1996. PMID: 8609216 Free PMC article.