Chiba J - Search Results

1

New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 4.

Takeda Y, Uoto K, Chiba J, Horiuchi T, Iwahana M, Atsumi R, Ono C, Terasawa H, Soga T. Takeda Y, et al. Among authors: chiba j. Bioorg Med Chem. 2003 Oct 1;11(20):4431-47. doi: 10.1016/s0968-0896(03)00454-1. Bioorg Med Chem. 2003. PMID: 13129580

2

New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 2.

Ishiyama T, Iimura S, Yoshino T, Chiba J, Uoto K, Terasawa H, Soga T. Ishiyama T, et al. Among authors: chiba j. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2815-9. doi: 10.1016/s0960-894x(02)00628-5. Bioorg Med Chem Lett. 2002. PMID: 12270153

3

New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 3.

Takeda Y, Yoshino T, Uoto K, Chiba J, Ishiyama T, Iwahana M, Jimbo T, Tanaka N, Terasawa H, Soga T. Takeda Y, et al. Among authors: chiba j. Bioorg Med Chem Lett. 2003 Jan 20;13(2):185-90. doi: 10.1016/s0960-894x(02)00891-0. Bioorg Med Chem Lett. 2003. PMID: 12482420

4

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships.

Horiuchi T, Chiba J, Uoto K, Soga T. Horiuchi T, et al. Among authors: chiba j. Bioorg Med Chem Lett. 2009 Jan 15;19(2):305-8. doi: 10.1016/j.bmcl.2008.11.090. Epub 2008 Nov 27. Bioorg Med Chem Lett. 2009. PMID: 19091560

5

Orally active docetaxel analogue: synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues.

Iimura S, Uoto K, Ohsuki S, Chiba J, Yoshino T, Iwahana M, Jimbo T, Terasawa H, Soga T. Iimura S, et al. Among authors: chiba j. Bioorg Med Chem Lett. 2001 Feb 12;11(3):407-10. doi: 10.1016/s0960-894x(00)00682-x. Bioorg Med Chem Lett. 2001. PMID: 11212122

6

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.

Chiba J, Iimura S, Yoneda Y, Watanabe T, Muro F, Tsubokawa M, Iigou Y, Satoh A, Takayama G, Yokoyama M, Takashi T, Nakayama A, Machinaga N. Chiba J, et al. Bioorg Med Chem. 2007 Feb 15;15(4):1679-93. doi: 10.1016/j.bmc.2006.12.006. Epub 2006 Dec 9. Bioorg Med Chem. 2007. PMID: 17194595

7

4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist.

Chiba J, Iimura S, Yoneda Y, Sugimoto Y, Horiuchi T, Muro F, Ochiai Y, Ogasawara T, Tsubokawa M, Iigou Y, Takayama G, Taira T, Takata Y, Yokoyama M, Takashi T, Nakayama A, Machinaga N. Chiba J, et al. Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1515-29. doi: 10.1248/cpb.54.1515. Chem Pharm Bull (Tokyo). 2006. PMID: 17077548 Free article.

8

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.

Muro F, Iimura S, Yoneda Y, Chiba J, Watanabe T, Setoguchi M, Takayama G, Yokoyama M, Takashi T, Nakayama A, Machinaga N. Muro F, et al. Among authors: chiba j. Bioorg Med Chem. 2009 Feb 1;17(3):1232-43. doi: 10.1016/j.bmc.2008.12.026. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19124247

9

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.

Chiba J, Machinaga N, Takashi T, Ejima A, Takayama G, Yokoyama M, Nakayama A, Baldwin JJ, McDonald E, Moriarty KJ, Sarko CR, Saionz KW, Swanson R, Hussain Z, Wong A. Chiba J, et al. Bioorg Med Chem Lett. 2005 Jan 3;15(1):41-5. doi: 10.1016/j.bmcl.2004.10.041. Bioorg Med Chem Lett. 2005. PMID: 15582407

10

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.

Chiba J, Takayama G, Takashi T, Yokoyama M, Nakayama A, Baldwin JJ, McDonald E, Moriarty KJ, Sarko CR, Saionz KW, Swanson R, Hussain Z, Wong A, Machinaga N. Chiba J, et al. Bioorg Med Chem. 2006 Apr 15;14(8):2725-46. doi: 10.1016/j.bmc.2005.11.058. Epub 2005 Dec 27. Bioorg Med Chem. 2006. PMID: 16377201

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