Bentley RG - Search Results

1

Novel cAMP PDE III inhibitors: 1,6-naphthyridin-2(1H)-ones.

Singh B, Lesher GY, Pluncket KC, Pagani ED, Bode DC, Bentley RG, Connell MJ, Hamel LT, Silver PJ. Singh B, et al. Among authors: bentley rg. J Med Chem. 1992 Dec 25;35(26):4858-65. doi: 10.1021/jm00104a012. J Med Chem. 1992. PMID: 1336055

2

Phosphodiesterase isozyme inhibition, activation of the cAMP system, and positive inotropy mediated by milrinone in isolated guinea pig cardiac muscle.

Silver PJ, Harris AL, Canniff PC, Lepore RE, Bentley RG, Hamel LT, Evans DB. Silver PJ, et al. Among authors: bentley rg. J Cardiovasc Pharmacol. 1989 Apr;13(4):530-40. J Cardiovasc Pharmacol. 1989. PMID: 2470989

3

Novel and potent adenosine 3',5'-cyclic phosphate phosphodiesterase III inhibitors: thiazolo[4,5-b][1,6]naphthyridin-2-ones.

Singh B, Bacon ER, Lesher GY, Robinson S, Pennock PO, Bode DC, Pagani ED, Bentley RG, Connell MJ, Hamel LT, et al. Singh B, et al. Among authors: bentley rg. J Med Chem. 1995 Jul 7;38(14):2546-50. doi: 10.1021/jm00014a007. J Med Chem. 1995. PMID: 7629794

4

Inhibition of low Km cGMP phosphodiesterases and Ca+(+)-regulated protein kinases and relationship to vasorelaxation by cicletanine.

Silver PJ, O'Connor B, Cumiskey WR, Van Aller G, Hamel LT, Bentley RG, Pagani ED. Silver PJ, et al. Among authors: bentley rg. J Pharmacol Exp Ther. 1991 Apr;257(1):382-91. J Pharmacol Exp Ther. 1991. PMID: 1850474

5

Cellular distribution and pharmacological sensitivity of low Km cyclic nucleotide phosphodiesterase isozymes in human cardiac muscle from normal and cardiomyopathic subjects.

Silver PJ, Allen P, Etzler JH, Hamel LT, Bentley RG, Pagani ED. Silver PJ, et al. Among authors: bentley rg. Second Messengers Phosphoproteins. 1990;13(1):13-25. Second Messengers Phosphoproteins. 1990. PMID: 2286932

6

Phosphodiesterase isozyme inhibition and the potentiation by zaprinast of endothelium-derived relaxing factor and guanylate cyclase stimulating agents in vascular smooth muscle.

Harris AL, Lemp BM, Bentley RG, Perrone MH, Hamel LT, Silver PJ. Harris AL, et al. Among authors: bentley rg. J Pharmacol Exp Ther. 1989 May;249(2):394-400. J Pharmacol Exp Ther. 1989. PMID: 2566675

7

Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle.

Silver PJ, Hamel LT, Perrone MH, Bentley RG, Bushover CR, Evans DB. Silver PJ, et al. Among authors: bentley rg. Eur J Pharmacol. 1988 May 20;150(1-2):85-94. doi: 10.1016/0014-2999(88)90753-4. Eur J Pharmacol. 1988. PMID: 2841146

8

Inhibition of the low Km cyclic AMP phosphodiesterase and activation of the cyclic AMP system in vascular smooth muscle by milrinone.

Silver PJ, Lepore RE, O'Connor B, Lemp BM, Hamel LT, Bentley RG, Harris AL. Silver PJ, et al. Among authors: bentley rg. J Pharmacol Exp Ther. 1988 Oct;247(1):34-42. J Pharmacol Exp Ther. 1988. PMID: 2845058

9

Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.

Goodman KB, Cui H, Dowdell SE, Gaitanopoulos DE, Ivy RL, Sehon CA, Stavenger RA, Wang GZ, Viet AQ, Xu W, Ye G, Semus SF, Evans C, Fries HE, Jolivette LJ, Kirkpatrick RB, Dul E, Khandekar SS, Yi T, Jung DK, Wright LL, Smith GK, Behm DJ, Bentley R, Doe CP, Hu E, Lee D. Goodman KB, et al. J Med Chem. 2007 Jan 11;50(1):6-9. doi: 10.1021/jm0609014. J Med Chem. 2007. PMID: 17201405

10

Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand.

Choi-Sledeski YM, Kearney R, Poli G, Pauls H, Gardner C, Gong Y, Becker M, Davis R, Spada A, Liang G, Chu V, Brown K, Collussi D, Leadley R Jr, Rebello S, Moxey P, Morgan S, Bentley R, Kasiewski C, Maignan S, Guilloteau JP, Mikol V. Choi-Sledeski YM, et al. J Med Chem. 2003 Feb 27;46(5):681-4. doi: 10.1021/jm020384z. J Med Chem. 2003. PMID: 12593648

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