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N-benzylideneaniline and N-benzylaniline are potent inhibitors of lignostilbene-alpha,beta-dioxygenase, a key enzyme in oxidative cleavage of the central double bond of lignostilbene.
Han SY, Inoue H, Terada T, Kamoda S, Saburi Y, Sekimata K, Saito T, Kobayashi M, Shinozaki K, Yoshida S, Asami T. Han SY, et al. Among authors: saito t. J Enzyme Inhib Med Chem. 2003 Jun;18(3):279-83. doi: 10.1080/1475636031000080207. J Enzyme Inhib Med Chem. 2003. PMID: 14506920 Free article.
Design and synthesis of lignostilbene-alpha,beta-dioxygenase inhibitors.
Han Sy, Inoue H, Terada T, Kamoda S, Saburi Y, Sekimata K, Saito T, Kobayashi M, Shinozaki K, Yoshida S, Asami T. Han Sy, et al. Among authors: saito t. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1139-42. doi: 10.1016/s0960-894x(02)00126-9. Bioorg Med Chem Lett. 2002. PMID: 11934574
Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.
Hullin-Matsuda F, Tomishige N, Sakai S, Ishitsuka R, Ishii K, Makino A, Greimel P, Abe M, Laviad EL, Lagarde M, Vidal H, Saito T, Osada H, Hanada K, Futerman AH, Kobayashi T. Hullin-Matsuda F, et al. Among authors: saito t. J Biol Chem. 2012 Jul 13;287(29):24397-411. doi: 10.1074/jbc.M112.344432. Epub 2012 May 17. J Biol Chem. 2012. PMID: 22605339 Free PMC article.
A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.
Yashiroda Y, Okamoto R, Hatsugai K, Takemoto Y, Goshima N, Saito T, Hamamoto M, Sugimoto Y, Osada H, Seimiya H, Yoshida M. Yashiroda Y, et al. Among authors: saito t. Biochem Biophys Res Commun. 2010 Apr 9;394(3):569-73. doi: 10.1016/j.bbrc.2010.03.021. Epub 2010 Mar 7. Biochem Biophys Res Commun. 2010. PMID: 20214890
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