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mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).
Lebedeva IV, Emdad L, Su ZZ, Gupta P, Sauane M, Sarkar D, Staudt MR, Liu SJ, Taher MM, Xiao R, Barral P, Lee SG, Wang D, Vozhilla N, Park ES, Chatman L, Boukerche H, Ramesh R, Inoue S, Chada S, Li R, De Pass AL, Mahasreshti PJ, Dmitriev IP, Curiel DT, Yacoub A, Grant S, Dent P, Senzer N, Nemunaitis JJ, Fisher PB. Lebedeva IV, et al. Among authors: chada s. Int J Oncol. 2007 Nov;31(5):985-1007. Int J Oncol. 2007. PMID: 17912425 Review.
Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
Huang EY, Madireddi MT, Gopalkrishnan RV, Leszczyniecka M, Su Z, Lebedeva IV, Kang D, Jiang H, Lin JJ, Alexandre D, Chen Y, Vozhilla N, Mei MX, Christiansen KA, Sivo F, Goldstein NI, Mhashilkar AB, Chada S, Huberman E, Pestka S, Fisher PB. Huang EY, et al. Among authors: chada s. Oncogene. 2001 Oct 25;20(48):7051-63. doi: 10.1038/sj.onc.1204897. Oncogene. 2001. PMID: 11704829
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
Chada S, Sutton RB, Ekmekcioglu S, Ellerhorst J, Mumm JB, Leitner WW, Yang HY, Sahin AA, Hunt KK, Fuson KL, Poìndexter N, Roth JA, Ramesh R, Grimm EA, Mhashilkar AM. Chada S, et al. Int Immunopharmacol. 2004 May;4(5):649-67. doi: 10.1016/j.intimp.2004.01.017. Int Immunopharmacol. 2004. PMID: 15120650 Review.
Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated -7 (mda-7)/interleukin-24 (IL-24) gene.
Saito Y, Miyahara R, Gopalan B, Litvak A, Inoue S, Shanker M, Branch CD, Mhashilkar AM, Roth JA, Chada S, Ramesh R. Saito Y, et al. Among authors: chada s. Cancer Gene Ther. 2005 Mar;12(3):238-47. doi: 10.1038/sj.cgt.7700780. Cancer Gene Ther. 2005. PMID: 15578066
Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.
Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K, Coffee K, Ramesh R, Ekmekcioglu S, Grimm EA, van Wart Hood J, Merritt J, Chada S. Tong AW, et al. Among authors: chada s. Mol Ther. 2005 Jan;11(1):160-72. doi: 10.1016/j.ymthe.2004.09.021. Mol Ther. 2005. PMID: 15585417 Free article. Clinical Trial.
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