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T cells require TRAIL for optimal graft-versus-tumor activity.
Schmaltz C, Alpdogan O, Kappel BJ, Muriglan SJ, Rotolo JA, Ongchin J, Willis LM, Greenberg AS, Eng JM, Crawford JM, Murphy GF, Yagita H, Walczak H, Peschon JJ, van den Brink MR. Schmaltz C, et al. Among authors: alpdogan o. Nat Med. 2002 Dec;8(12):1433-7. doi: 10.1038/nm1202-797. Epub 2002 Nov 11. Nat Med. 2002. PMID: 12426560
Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model.
Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper TS, Burakoff SJ. Friedman JS, et al. Among authors: alpdogan o. Biol Blood Marrow Transplant. 2004 Jul;10(7):448-60. doi: 10.1016/j.bbmt.2004.03.005. Biol Blood Marrow Transplant. 2004. PMID: 15205666 Free article.
GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease.
Muriglan SJ, Ramirez-Montagut T, Alpdogan O, Van Huystee TW, Eng JM, Hubbard VM, Kochman AA, Tjoe KH, Riccardi C, Pandolfi PP, Sakaguchi S, Houghton AN, Van Den Brink MR. Muriglan SJ, et al. Among authors: alpdogan o. J Exp Med. 2004 Jul 19;200(2):149-57. doi: 10.1084/jem.20040116. Epub 2004 Jul 12. J Exp Med. 2004. PMID: 15249593 Free PMC article.
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