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Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors.
Bruno V, Battaglia G, Kingston A, O'Neill MJ, Catania MV, Di Grezia R, Nicoletti F. Bruno V, et al. Among authors: nicoletti f. Neuropharmacology. 1999 Feb;38(2):199-207. doi: 10.1016/s0028-3908(98)00159-2. Neuropharmacology. 1999. PMID: 10218860
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
Gasparini F, Bruno V, Battaglia G, Lukic S, Leonhardt T, Inderbitzin W, Laurie D, Sommer B, Varney MA, Hess SD, Johnson EC, Kuhn R, Urwyler S, Sauer D, Portet C, Schmutz M, Nicoletti F, Flor PJ. Gasparini F, et al. Among authors: nicoletti f. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87. J Pharmacol Exp Ther. 1999. PMID: 10336568
991 results