Puri RK - Search Results

1

Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.

de Jong MC, Scheffer GL, Broxterman HJ, Hooijberg JH, Slootstra JW, Meloen RH, Kreitman RJ, Husain SR, Joshi BH, Puri RK, Scheper RJ. de Jong MC, et al. Among authors: puri rk. Clin Cancer Res. 2003 Oct 15;9(13):5009-17. Clin Cancer Res. 2003. PMID: 14581376

2

Expression of high-affinity interleukin 4 receptors on murine sarcoma cells and receptor-mediated cytotoxicity of tumor cells to chimeric protein between interleukin 4 and Pseudomonas exotoxin.

Puri RK, Ogata M, Leland P, Feldman GM, FitzGerald D, Pastan I. Puri RK, et al. Cancer Res. 1991 Jun 1;51(11):3011-7. Cancer Res. 1991. PMID: 2032239

3

Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.

Kreitman RJ, Puri RK, Pastan I. Kreitman RJ, et al. Among authors: puri rk. Cancer Res. 1995 Aug 1;55(15):3357-63. Cancer Res. 1995. PMID: 7614471

4

Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity.

Kreitman RJ, Puri RK, Leland P, Lee B, Pastan I. Kreitman RJ, et al. Among authors: puri rk. Biochemistry. 1994 Sep 27;33(38):11637-44. doi: 10.1021/bi00204a027. Biochemistry. 1994. PMID: 7918378

5

A circularly permuted recombinant interleukin 4 toxin with increased activity.

Kreitman RJ, Puri RK, Pastan I. Kreitman RJ, et al. Among authors: puri rk. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6889-93. doi: 10.1073/pnas.91.15.6889. Proc Natl Acad Sci U S A. 1994. PMID: 8041715 Free PMC article.

6

Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein.

Puri RK, Leland P, Kreitman RJ, Pastan I. Puri RK, et al. Int J Cancer. 1994 Aug 15;58(4):574-81. doi: 10.1002/ijc.2910580421. Int J Cancer. 1994. PMID: 8056454

7

Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin.

Puri RK, Debinski W, Obiri N, Kreitman R, Pastan I. Puri RK, et al. Cell Immunol. 1994 Apr 1;154(1):369-79. doi: 10.1006/cimm.1994.1084. Cell Immunol. 1994. PMID: 8131209

8

A chimeric protein comprised of IL-4 and Pseudomonas exotoxin is cytotoxic for activated human lymphocytes.

Puri RK, Mehrotra PT, Leland P, Kreitman RJ, Siegel JP, Pastan I. Puri RK, et al. J Immunol. 1994 Apr 1;152(7):3693-700. J Immunol. 1994. PMID: 8144944

9

A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin.

Debinski W, Puri RK, Kreitman RJ, Pastan I. Debinski W, et al. Among authors: puri rk. J Biol Chem. 1993 Jul 5;268(19):14065-70. J Biol Chem. 1993. PMID: 8314773 Free article.

10

Circularly permuted interleukin 4 retains proliferative and binding activity.

Kreitman RJ, Puri RK, McPhie P, Pastan I. Kreitman RJ, et al. Among authors: puri rk. Cytokine. 1995 May;7(4):311-8. doi: 10.1006/cyto.1995.0039. Cytokine. 1995. PMID: 8589260

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