Shifman JM - Search Results

1

Exploring the origins of binding specificity through the computational redesign of calmodulin.

Shifman JM, Mayo SL. Shifman JM, et al. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13274-9. doi: 10.1073/pnas.2234277100. Epub 2003 Nov 3. Proc Natl Acad Sci U S A. 2003. PMID: 14597710 Free PMC article.

2

Computational design of an integrin I domain stabilized in the open high affinity conformation.

Shimaoka M, Shifman JM, Jing H, Takagi J, Mayo SL, Springer TA. Shimaoka M, et al. Among authors: shifman jm. Nat Struct Biol. 2000 Aug;7(8):674-8. doi: 10.1038/77978. Nat Struct Biol. 2000. PMID: 10932253

3

Modulating calmodulin binding specificity through computational protein design.

Shifman JM, Mayo SL. Shifman JM, et al. J Mol Biol. 2002 Oct 25;323(3):417-23. doi: 10.1016/s0022-2836(02)00881-1. J Mol Biol. 2002. PMID: 12381298

4

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums.

Shifman JM, Choi MH, Mihalas S, Mayo SL, Kennedy MB. Shifman JM, et al. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13968-73. doi: 10.1073/pnas.0606433103. Epub 2006 Sep 11. Proc Natl Acad Sci U S A. 2006. PMID: 16966599 Free PMC article.

5

Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21.

Leung I, Dekel A, Shifman JM, Sidhu SS. Leung I, et al. Among authors: shifman jm. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8705-10. doi: 10.1073/pnas.1524648113. Epub 2016 Jul 19. Proc Natl Acad Sci U S A. 2016. PMID: 27436899 Free PMC article.

6

Computational design of calmodulin mutants with up to 900-fold increase in binding specificity.

Yosef E, Politi R, Choi MH, Shifman JM. Yosef E, et al. Among authors: shifman jm. J Mol Biol. 2009 Feb 6;385(5):1470-80. doi: 10.1016/j.jmb.2008.09.053. Epub 2008 Sep 27. J Mol Biol. 2009. PMID: 18845160

7

Computational methods for controlling binding specificity.

Sharabi O, Erijman A, Shifman JM. Sharabi O, et al. Among authors: shifman jm. Methods Enzymol. 2013;523:41-59. doi: 10.1016/B978-0-12-394292-0.00003-5. Methods Enzymol. 2013. PMID: 23422425

8

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution.

Arkadash V, Yosef G, Shirian J, Cohen I, Horev Y, Grossman M, Sagi I, Radisky ES, Shifman JM, Papo N. Arkadash V, et al. Among authors: shifman jm. J Biol Chem. 2017 Feb 24;292(8):3481-3495. doi: 10.1074/jbc.M116.756718. Epub 2017 Jan 13. J Biol Chem. 2017. PMID: 28087697 Free PMC article.

9

Alteration of the C-terminal ligand specificity of the erbin PDZ domain by allosteric mutational effects.

Murciano-Calles J, McLaughlin ME, Erijman A, Hooda Y, Chakravorty N, Martinez JC, Shifman JM, Sidhu SS. Murciano-Calles J, et al. Among authors: shifman jm. J Mol Biol. 2014 Oct 23;426(21):3500-8. doi: 10.1016/j.jmb.2014.05.003. Epub 2014 May 9. J Mol Biol. 2014. PMID: 24813123

10

Analysis of Structural Features Contributing to Weak Affinities of Ubiquitin/Protein Interactions.

Cohen A, Rosenthal E, Shifman JM. Cohen A, et al. Among authors: shifman jm. J Mol Biol. 2017 Nov 10;429(22):3353-3362. doi: 10.1016/j.jmb.2017.09.003. Epub 2017 Sep 11. J Mol Biol. 2017. PMID: 28911847 Review.

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