Benson N - Search Results

1

Development of a 1-microl scale assay for mitogen-activated kinase kinase 7 using 2-D fluorescence intensity distribution analysis anisotropy.

Wright PA, Boyd HF, Bethell RC, Busch M, Gribbon P, Kraemer J, Lopez-Calle E, Mander TH, Winkler D, Benson N. Wright PA, et al. Among authors: benson n. J Biomol Screen. 2002 Oct;7(5):419-28. doi: 10.1177/108705702237673. J Biomol Screen. 2002. PMID: 14599357

2

NanoStore: a concept for logistical improvements of compound handling in high-throughput screening.

Benson N, Boyd HF, Everett JR, Fries J, Gribbon P, Haque N, Henco K, Jessen T, Martin WH, Mathewson TJ, Sharp RE, Spencer RW, Stuhmeier F, Wallace MS, Winkler D. Benson N, et al. J Biomol Screen. 2005 Sep;10(6):573-80. doi: 10.1177/1087057105277234. Epub 2005 Jun 24. J Biomol Screen. 2005. PMID: 16103412

3

Improving the design and analysis of high-throughput screening technology comparison experiments using statistical modeling.

Woodward PW, Williams C, Sewing A, Benson N. Woodward PW, et al. Among authors: benson n. J Biomol Screen. 2006 Feb;11(1):5-12. doi: 10.1177/1087057105280779. Epub 2005 Oct 18. J Biomol Screen. 2006. PMID: 16234338

4

Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.

Benson N, Snelder N, Ploeger B, Napier C, Sale H, Birdsall NJ, Butt RP, van der Graaf PH. Benson N, et al. Br J Pharmacol. 2010 May;160(2):389-98. doi: 10.1111/j.1476-5381.2010.00719.x. Br J Pharmacol. 2010. PMID: 20423348 Free PMC article.

5

Model-based drug development: a rational approach to efficiently accelerate drug development.

Milligan PA, Brown MJ, Marchant B, Martin SW, van der Graaf PH, Benson N, Nucci G, Nichols DJ, Boyd RA, Mandema JW, Krishnaswami S, Zwillich S, Gruben D, Anziano RJ, Stock TC, Lalonde RL. Milligan PA, et al. Among authors: benson n. Clin Pharmacol Ther. 2013 Jun;93(6):502-14. doi: 10.1038/clpt.2013.54. Epub 2013 Mar 14. Clin Pharmacol Ther. 2013. PMID: 23588322

6

Translational pharmacokinetic-pharmacodynamic modelling; application to cardiovascular safety data for PF-00821385, a novel HIV agent.

Langdon G, Davis JD, McFadyen LM, Dewhurst M, Brunton NS, Rawal JK, Van der Graaf PH, Benson N. Langdon G, et al. Among authors: benson n. Br J Clin Pharmacol. 2010 Apr;69(4):336-45. doi: 10.1111/j.1365-2125.2009.03594.x. Br J Clin Pharmacol. 2010. PMID: 20406218 Free PMC article. Clinical Trial.

7

Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.

Tran TD, Pryde DC, Jones P, Adam FM, Benson N, Bish G, Calo F, Ciaramella G, Dixon R, Duckworth J, Fox DN, Hay DA, Hitchin J, Horscroft N, Howard M, Gardner I, Jones HM, Laxton C, Parkinson T, Parsons G, Proctor K, Smith MC, Smith N, Thomas A. Tran TD, et al. Among authors: benson n. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2389-93. doi: 10.1016/j.bmcl.2011.02.092. Epub 2011 Mar 16. Bioorg Med Chem Lett. 2011. PMID: 21419626

8

Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development.

van der Graaf PH, Benson N. van der Graaf PH, et al. Among authors: benson n. Pharm Res. 2011 Jul;28(7):1460-4. doi: 10.1007/s11095-011-0467-9. Epub 2011 May 11. Pharm Res. 2011. PMID: 21560018

9

Reducing systems biology to practice in pharmaceutical company research; selected case studies.

Benson N, Cucurull-Sanchez L, Demin O, Smirnov S, van der Graaf P. Benson N, et al. Adv Exp Med Biol. 2012;736:607-15. doi: 10.1007/978-1-4419-7210-1_36. Adv Exp Med Biol. 2012. PMID: 22161355

10

Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is.

Benson N. Benson N. Drug Discov Today Technol. 2015 Aug;15:41-8. doi: 10.1016/j.ddtec.2015.07.003. Epub 2015 Sep 10. Drug Discov Today Technol. 2015. PMID: 26464089 Review.

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