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3,507 results

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Page 1
Design and synthesis of statine-containing BACE inhibitors.
Hu J, Cwi CL, Smiley DL, Timm D, Erickson JA, McGee JE, Yang HC, Mendel D, May PC, Shapiro M, McCarthy JR. Hu J, et al. Among authors: shapiro m. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4335-9. doi: 10.1016/j.bmcl.2003.09.037. Bioorg Med Chem Lett. 2003. PMID: 14643321
ID NMR Methods in ligand-receptor interactions.
Zartler ER, Yan J, Mo H, Kline AD, Shapiro MJ. Zartler ER, et al. Curr Top Med Chem. 2003;3(1):25-37. doi: 10.2174/1568026033392750. Curr Top Med Chem. 2003. PMID: 12577989 Review.
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.
Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, DePianta RP, Fish PV, Heifetz A, Ho DK, Jessiman AS, McMurray G, de Oliveira CA, Roberts LR, Root JA, Shanmugasundaram V, Shapiro MJ, Skerten M, Westbrook D, Wheeler S, Whitlock GA, Wright J. Storer RI, et al. Among authors: shapiro mj. J Med Chem. 2014 Jun 26;57(12):5258-69. doi: 10.1021/jm5003292. Epub 2014 Jun 17. J Med Chem. 2014. PMID: 24878222
Fragonomics: fragment-based drug discovery.
Zartler ER, Shapiro MJ. Zartler ER, et al. Curr Opin Chem Biol. 2005 Aug;9(4):366-70. doi: 10.1016/j.cbpa.2005.05.002. Curr Opin Chem Biol. 2005. PMID: 15925537 Review.
Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.
Flanagan ME, Abramite JA, Anderson DP, Aulabaugh A, Dahal UP, Gilbert AM, Li C, Montgomery J, Oppenheimer SR, Ryder T, Schuff BP, Uccello DP, Walker GS, Wu Y, Brown MF, Chen JM, Hayward MM, Noe MC, Obach RS, Philippe L, Shanmugasundaram V, Shapiro MJ, Starr J, Stroh J, Che Y. Flanagan ME, et al. Among authors: shapiro mj. J Med Chem. 2014 Dec 11;57(23):10072-9. doi: 10.1021/jm501412a. Epub 2014 Nov 26. J Med Chem. 2014. PMID: 25375838
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, Wagenaar MM, Shapiro MJ, Musto S, Lam MH, Loganzo F, O'Donnell CJ. Maderna A, et al. Among authors: shapiro mj. J Med Chem. 2014 Dec 26;57(24):10527-43. doi: 10.1021/jm501649k. Epub 2014 Dec 9. J Med Chem. 2014. PMID: 25431858
3,507 results