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Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo.
Friedberg JW, Dong DA, Li S, Kim H, Stephans K, Noonan K, Neuberg D, Gribben JG, Fisher DC, Freedman AS, Takvorian T, Jurgens R, Battle TE, Frank DA. Friedberg JW, et al. Among authors: neuberg d. Leuk Res. 2004 Feb;28(2):139-47. doi: 10.1016/s0145-2126(03)00213-3. Leuk Res. 2004. PMID: 14654078 Clinical Trial.
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