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Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist.
Lee J, Seo HJ, Lee SH, Kim J, Jung ME, Lee SH, Song KS, Lee J, Kang SY, Kim MJ, Kim MS, Son EJ, Lee M, Han HK. Lee J, et al. Bioorg Med Chem. 2010 Sep 1;18(17):6377-88. doi: 10.1016/j.bmc.2010.07.013. Epub 2010 Jul 30. Bioorg Med Chem. 2010. PMID: 20673729
Substituted pyrimidines as cannabinoid CB1 receptor ligands.
Kim MJ, Kim JY, Seo HJ, Lee J, Lee SH, Kim MS, Kang J, Kim J, Lee J. Kim MJ, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4692-7. doi: 10.1016/j.bmcl.2009.06.069. Epub 2009 Jun 21. Bioorg Med Chem Lett. 2009. PMID: 19596576
8,947 results