Akao Y - Search Results

1

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.

Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Yodim M, Furukawa S, Nabeshima T, Naoi M. Maruyama W, et al. Among authors: akao y. Neurochem Int. 2004 May;44(6):393-400. doi: 10.1016/j.neuint.2003.08.005. Neurochem Int. 2004. PMID: 14687604

2

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan.

Akao Y, Maruyama W, Shimizu S, Yi H, Nakagawa Y, Shamoto-Nagai M, Youdim MB, Tsujimoto Y, Naoi M. Akao Y, et al. J Neurochem. 2002 Aug;82(4):913-23. doi: 10.1046/j.1471-4159.2002.01047.x. J Neurochem. 2002. PMID: 12358797 Free article.

3

Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells.

Yi H, Akao Y, Maruyama W, Chen K, Shih J, Naoi M. Yi H, et al. Among authors: akao y. J Neurochem. 2006 Jan;96(2):541-9. doi: 10.1111/j.1471-4159.2005.03573.x. Epub 2005 Dec 8. J Neurochem. 2006. PMID: 16336631 Free article.

4

Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol.

Maruyama W, Akao Y, Youdim MB, Davis BA, Naoi M. Maruyama W, et al. Among authors: akao y. J Neurochem. 2001 Aug;78(4):727-35. doi: 10.1046/j.1471-4159.2001.00448.x. J Neurochem. 2001. PMID: 11520893 Free article.

5

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022.

Maruyama W, Akao Y, Youdim MB, Naoi M. Maruyama W, et al. Among authors: akao y. J Neural Transm Suppl. 2000;(60):171-86. doi: 10.1007/978-3-7091-6301-6_11. J Neural Transm Suppl. 2000. PMID: 11205138

6

Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component.

Naoi M, Maruyama W, Yi H, Yamaoka Y, Shamoto-Nagai M, Akao Y, Gerlach M, Tanaka M, Riederer P. Naoi M, et al. Among authors: akao y. J Neurochem. 2008 Jun 1;105(6):2489-500. doi: 10.1111/j.1471-4159.2008.05329.x. J Neurochem. 2008. PMID: 18399961 Free article.

7

Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells.

Inaba-Hasegawa K, Akao Y, Maruyama W, Naoi M. Inaba-Hasegawa K, et al. Among authors: akao y. J Neural Transm (Vienna). 2013 Mar;120(3):435-44. doi: 10.1007/s00702-012-0899-3. Epub 2012 Sep 12. J Neural Transm (Vienna). 2013. PMID: 22968599

8

An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells.

Akao Y, Maruyama W, Yi H, Shamoto-Nagai M, Youdim MB, Naoi M. Akao Y, et al. Neurosci Lett. 2002 Jun 28;326(2):105-8. doi: 10.1016/s0304-3940(02)00332-4. Neurosci Lett. 2002. PMID: 12057839

9

Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes.

Maruyama W, Akao Y, Carrillo MC, Kitani K, Youdium MB, Naoi M. Maruyama W, et al. Among authors: akao y. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):675-82. doi: 10.1016/s0892-0362(02)00221-0. Neurotoxicol Teratol. 2002. PMID: 12200198 Review.

10

Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells.

Shamoto-Nagai M, Maruyama W, Akao Y, Osawa T, Tribl F, Gerlach M, Zucca FA, Zecca L, Riederer P, Naoi M. Shamoto-Nagai M, et al. Among authors: akao y. J Neural Transm (Vienna). 2004 Oct;111(10-11):1253-65. doi: 10.1007/s00702-004-0211-2. J Neural Transm (Vienna). 2004. PMID: 15480837

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