Houghton JA - Search Results

1

Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin.

Geller J, Petak I, Szucs KS, Nagy K, Tillman DM, Houghton JA. Geller J, et al. Among authors: houghton ja. Clin Cancer Res. 2003 Dec 15;9(17):6504-15. Clin Cancer Res. 2003. PMID: 14695155

2

Modulation of the Fas signaling pathway by IFN-gamma in therapy of colon cancer: phase I trial and correlative studies of IFN-gamma, 5-fluorouracil, and leucovorin.

Schwartzberg LS, Petak I, Stewart C, Turner PK, Ashley J, Tillman DM, Douglas L, Tan M, Billups C, Mihalik R, Weir A, Tauer K, Shope S, Houghton JA. Schwartzberg LS, et al. Among authors: houghton ja. Clin Cancer Res. 2002 Aug;8(8):2488-98. Clin Cancer Res. 2002. PMID: 12171874 Clinical Trial.

3

Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.

Tillman DM, Izeradjene K, Szucs KS, Douglas L, Houghton JA. Tillman DM, et al. Among authors: houghton ja. Cancer Res. 2003 Aug 15;63(16):5118-25. Cancer Res. 2003. PMID: 12941843

4

Interferon-gamma pharmacokinetics and pharmacodynamics in patients with colorectal cancer.

Turner PK, Houghton JA, Petak I, Tillman DM, Douglas L, Schwartzberg L, Billups CA, Panetta JC, Stewart CF. Turner PK, et al. Among authors: houghton ja. Cancer Chemother Pharmacol. 2004 Mar;53(3):253-60. doi: 10.1007/s00280-003-0723-8. Epub 2003 Nov 28. Cancer Chemother Pharmacol. 2004. PMID: 14648016 Clinical Trial.

5

P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.

Geller JI, Szekely-Szucs K, Petak I, Doyle B, Houghton JA. Geller JI, et al. Among authors: houghton ja. Cancer Res. 2004 Sep 1;64(17):6296-303. doi: 10.1158/0008-5472.CAN-04-0863. Cancer Res. 2004. PMID: 15342418

6

Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.

Izeradjene K, Douglas L, Tillman DM, Delaney AB, Houghton JA. Izeradjene K, et al. Among authors: houghton ja. Cancer Res. 2005 Aug 15;65(16):7436-45. doi: 10.1158/0008-5472.CAN-04-2628. Cancer Res. 2005. PMID: 16103097

7

Thymineless death in colon carcinoma cells is mediated via fas signaling.

Houghton JA, Harwood FG, Tillman DM. Houghton JA, et al. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8144-9. doi: 10.1073/pnas.94.15.8144. Proc Natl Acad Sci U S A. 1997. PMID: 9223329 Free PMC article.

8

Selective sensitization to DNA-damaging agents in a human rhabdomyosarcoma cell line with inducible wild-type p53 overexpression.

Gibson AA, Harwood FG, Tillman DM, Houghton JA. Gibson AA, et al. Among authors: houghton ja. Clin Cancer Res. 1998 Jan;4(1):145-52. Clin Cancer Res. 1998. PMID: 9516963

9

The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis.

Houghton JA, Harwood FG, Gibson AA, Tillman DM. Houghton JA, et al. Clin Cancer Res. 1997 Dec;3(12 Pt 1):2205-9. Clin Cancer Res. 1997. PMID: 9815616

10

Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.

Houghton JA, Tillman DM, Harwood FG. Houghton JA, et al. Clin Cancer Res. 1995 Jul;1(7):723-30. Clin Cancer Res. 1995. PMID: 9816038

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